Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis

Squamous cell cancers of the head and neck as a group represent the sixth most common malignancy worldwide [1]. While the overall incidence of head and neck cancers (HNC) at various anatomic subsites such as the ventrolateral tongue and floor of mouth has decreased in conjunction with reduced smoking and drinking rates, oropharyngeal squamous cell carcinomas (OPSCC) have increased mainly due to high-risk human papillomavirus (HPV) infection [2]. HPV is a sexually transmitted infection, and currently recognized as the most prevalent sexually transmitted infection in the United States [3].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research