Acute liver failure and liver transplantation in a patient with multiple sclerosis treated with interferon beta

Publication date: November–December 2015 Source:Neurologia i Neurochirurgia Polska, Volume 49, Issue 6 Author(s): Dorota Kozielewicz, Małgorzata Pawłowska In the treatment of multiple sclerosis (MS), interferon beta (IFNβ) applies. It rarely can lead to acute liver failure (ALF). A 42-year-old female with MS was admitted to the Department because of jaundice, general weakness, drowsiness and nausea. Four weeks earlier, she had started therapy with IFNβ-1a. Liver tests made prior to initiation of IFNβ-1a were normal but on admission to the Department exceed several times the upper limit. ALF was recognized and IFNβ-1a was immediately stopped. In the fourth day of hospitalization, symptoms of hepatic encephalopathy have progressed. The patient was transferred to the Department of Transplantation, where hepatic coma developed and three days later the orthotopic liver transplantation was performed. In histopathological picture of the removed liver extensive necrosis and fibrosis dominated. Immunosuppressive therapy consisted of tacrolimus, mycophenolate mofetil and tapering prednisone. Within five years after surgery, there was no recurrence of symptoms of MS and the transplanted organ is functioning properly. ALF is a rare complication of IFNβ therapy but it can occur. The appearance of symptoms suggestive of liver injury should prompt extension of diagnosis and, if necessary, discontinuation of therapy.
Source: Polish Journal of Neurology and Neurosurgery - Category: Neurosurgery Source Type: research

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Publication date: Available online 9 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Brenda Bertado-Cortés, Claudia Venzor-Mendoza, Daniel Rubio-Ordoñez, José Renán Pérez-Pérez, Lucy Andrea Novelo-Manzano, Lyda Viviana Villamil-Osorio, María de Jesús Jiménez-Ortega, María de la Luz Villalpando-Gueich, Nayeli Alejandra Sánchez-Rosales, Verónica García-Talavera
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
CONCLUSIONS: Tacrolimus may be a safe and effective immunosuppressant for refractory or relapsing form of orbital or cranial IIPs. PMID: 33029975 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Conclusion: HS is a severe condition marked by an excessive activation of the immune system that leads to a rapid and progressive multi-organ failure, so it is important to consider it in the differential diagnosis of a fever syndrome following the administration of alemtuzumab.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: HS is a severe condition marked by an excessive activation of the immune system that leads to a rapid and progressive multi-organ failure, so it is important to consider it in the differential diagnosis of a fever syndrome following the administration of alemtuzumab.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We present a 45-year-old Caucasian woman with a history of multiple sclerosis who presented to the hospital with 4 weeks of epigastric pain, nausea, intermittent bilious emesis, and new jaundice. She reported daily intake of 2 –3 glasses of wine over the past 15 years. She denied recent travel or use of acetaminophen, herbal supplements, or any new medications. Laboratory results showed hemoglobin of 11.6 g/dL, white blood cell count of 16.0 × 103/μL, and a platelet count of 272 × 103/μL.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Clinical Challenges and Images in GI Source Type: research
We present a 45-year-old Caucasian woman with a history of multiple sclerosis who presented to the hospital with 4 weeks of epigastric pain, nausea, intermittent bilious emesis, and new jaundice. She reported daily intake of 2 –3 glasses of wine over the past 15 years. She denied recent travel or use of acetaminophen, herbal supplements, or any new medications. Laboratory results showed hemoglobin of 11.6 g/dL, white blood cell count of 16.0 × 103/μL, and a platelet count of 272 × 103/μL.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Clinical Challenges and Images in GI Source Type: research
This article brings the choroid plexus into the context of health and disease. It is remarkable that the choroid plexus, composed by the monolayer of epithelial cells that lie in a highly vascularized stroma, floating within the brain ventricles, gets so little attention in major physiology and medicine text books and in the scientific literature in general. Consider that it is responsible for producing most of the about 150mL of cerebrospinal fluid that fills the brain ventricles and the subarachnoid space and surrounds the spinal cord in the adult human brain, which is renewed approximately 2-3 times daily. As such, its ...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
Conclusions The hepatitis B vaccination program targeting newborns and infants does NOT make sense. The vaccination itself has not proven to be effective in preventing hepatitis B. There is very little risk of children becoming infected with hepatitis B. Hepatitis B is a disease that is not highly infectious and tends to affect adults in high risk groups. The course of the disease is usually self-limiting with lifelong immunity acquired. In contrast, many serious health consequences have resulted from the hepatitis B vaccination, including permanent disability and death.   References http://www.nvic.org/nvic-archives...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Top Stories adverse reactions Hepatitis B vaccine truth about vaccines Source Type: blogs
There’s something you should know about chronic kidney disease. Most doctors will tell you there is no alternative treatments for kidney problems besides costly dialysis or a transplant to deal with impaired renal function. What Is Kidney Failure? Kidney dialysis is a treatment that uses a special machine to filter harmful wastes, salt and excess from your blood. But there is another option. It’s called stem cell biotherapy, and it offers new hope to those with this life-threatening disease. You may think your kidneys are just fine and you have nothing to worry about. But consider this… What Causes Kidn...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
CONCLUSIONS: This case of fatal autoimmune hemolytic anemia associated with alemtuzumab treatment adds further evidence to the potential risk of antibody mediated side effects and argues for close hematological monitoring of patients.Disclosure: Dr. Rieckmann has received personal compensation for activities with Bayer, Biogen Idec, Boehringer Ingelheim, Novartis, Merck-Serono, Teva, and Genzyme. Dr. Lenz has nothing to disclose. Dr. Hoffmann has nothing to disclose. Dr. Poske has nothing to disclose. Dr. Behr has nothing to disclose. Dr. Kallmann has received honoraria for serving on advisory boards and as speaker from Me...
Source: Neurology - Category: Neurology Authors: Tags: MS and CNS Inflammatory Disease: Treatment, Safety, and Tolerance Source Type: research
More News: Brain | Jaundice | Liver | Liver Transplant | Multiple Sclerosis | Neurology | Neurosurgery | Prednisone | Prograf | Tacrolimus | Transplants | Urology & Nephrology