Ancillary procedures in the diagnostics of brain death : Utilization, results and consequences in northeastern Germany.

CONCLUSION: ATs by themselves do not provide evidence of the cessation of all brain functions. Instead, they are used to prove the irreversibility of the clinically defined syndrome. For patients over 2 years old and in the absence of primary brainstem lesions, clinical re-assessment and ATs are considered to be equally accurate in demonstrating irreversibility. A standardization of diagnostic procedures between hospitals would be desirable. PMID: 26781244 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research

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Source: Gut Microbes - Category: Microbiology Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Miriam Zeillemaker - Hoekstra, Carlijn I. Buis, Vlado Cernak, Koen MEM. ReyntjensAbstractThe combined transplantation of a thoracic organ and the liver is performed in patients with dual-organ failure in whom survival is not expected with single-organ transplantation alone. Although uncommonly performed, the number of combined liver-lung and liver-heart transplants is increasing. Anesthetic management of this complex procedure is challenging. Major blood loss, prolonged operation time, difficult weaning ...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
Publication date: Available online 25 January 2020Source: Stem Cell ResearchAuthor(s): Yuan Gao, Yanlin Wang, Zhuoya Wang, Huifang Sun, Rui Zhang, Jing Yang, Yutao Liu, Han Liu, Qi Zhang, Shoutao Zhang, Changhe Shi, Yuming Xu, Bo SongAbstractDermal fibroblasts obtained from a 43-year-old healthy man were successfully transformed into induced pluripotent stem cells (iPSCs) by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, and L-MYC. The iPSCs showed a normal karyotype and exhibited the potential to differentiate into three germ layers in a teratoma assay, which is often used to assess the pluripotency of ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 24 January 2020Source: CytotherapyAuthor(s): M. Teresa Donato, Miguel Bolonio, Estefanía Cabezas, María Pelechá, Eugenia Pareja, Anna Domènech, José V. Castell, M. José Gómez-lechón, Laia TolosaAbstractClinical hepatocyte transplantation short-term efficacy has been demonstrated; however, some major limitations, mainly due to the shortage of organs, the lack of quality of isolated cells and the low cell engraftment after transplantation, should be solved for increasing its efficacy in clinical applications. Cellular stress during iso...
Source: Cytotherapy - Category: Cytology Source Type: research
We examined whether Rhy promotes this regulation in bone marrow human mesenchymal stromal cells (BM-hMSCs). Results revealed (i) Rhy modulated biological activity by regulating the mitochondria, N-methyl-D-aspartate receptor subunit, and levels of FGFβ (basic fibroblast growth factor), BDNF (brain-derived neurotrophic factor), OXTR (oxytocin receptor) and ATP (Adenosine triphosphate); (ii) Rhy altered expression level of BM-MSC proliferation/differentiation-related transcription genes; and (iii) interestingly, Rhy amplified the glycolytic flow ratio and lactate dehydrogenase activity while reducing pyruvate dehydrogen...
Source: Cytotherapy - Category: Cytology Source Type: research
Bilateral renal agenesis has historically been described as “incompatible with life” as chronic anhydramnios results in pulmonary hypoplasia, leading to respiratory failure at birth. Recent reports have detailed the survival of infants with renal disease and severe oligo-/anhydramnios following prenatal serial amnioinfusions as a bridge to neonatal dialy sis with the goal of pediatric kidney transplant. Subsequently, clinical trials have proposed treating fetuses with bilateral renal agenesis with serial prenatal amnioinfusions to allow for pulmonary maturation and the potential for long-term survival.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
As palliative medicine expands within the scope of care for patients with cancer, the interface between hematologic malignancies and palliative care is increasing. These patients are underrepresented compared to their solid tumor counterparts regarding palliative care consultation. A growing body of literature supports earlier palliative care for patients with hematologic malignancies. From the impact of palliative care on bone marrow transplant patients' quality of life, utility of informatics in symptom assessment, and the role of transfusions in medical decision making regarding hospice, palliative medicine providers ar...
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Therapeutic yoga (TY) gently supports the body in therapeutic positions and may include relaxation breathing, comforting touch, and mindfulness meditation (MM). Evidence suggests that yoga, relaxation, and MM can help reduce anxiety, pain, nausea, and constipation. We piloted a feasibility project at a large New York teaching hospital to expand an established palliative care TY/MM program to include supportive cardiology patients. These are patients with advanced heart failure who are often awaiting (or have received) cardiac transplant, ventricular assistive devices, or total artificial heart support.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Hematopoietic stem cell transplantation (HSCT) is potentially curative for children with life-threatening conditions but can result in a high symptom burden and poor quality of life (QoL). Parents provide extensive care for their children and can experience psychological distress.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Hematopoietic cell transplant (HCT) carries a high risk of morbidity and mortality. Palliative care (PC) integration in HCT may improve patient/caregiver outcomes, however little is known about the impact of PC involvement on end-of-life care in pediatric HCT.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
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