Teens and medicines that cause birth defects: Do doctors drop the ball?

My 14-year-old daughter recently started taking isotretinoin, a medication that can help severe acne — and that can cause severe birth defects. I knew that there was a process in place for preventing pregnancy in girls taking it, but I was caught off guard by just how many hoops we had to jump through to get her prescription. There were two pregnancy tests a month apart at the beginning, continued monthly pregnancy tests as well as monthly online questions about contraception and her understanding of the effects of the medicine, and a special ID card that has to be brought to the pharmacy within a very short window after the monthly blood tests. I’d never seen anything like it, and I’m a doctor. It got me thinking: Why don’t we do this kind of thing for all the medications that cause birth defects? Are we dropping the ball? The answer, says a recent study published in the journal Pediatrics, is yes. For the study, researchers looked at 4,172 visits to a large Midwestern academic pediatric center. They found that 1,694 girls ages 14 to 25 got 4,506 prescriptions for Category D or X medications. Category D medications can cause birth defects, but in some cases the benefits outweigh the risks for a pregnant woman; for Category X medications, it’s felt that the risks outweigh the benefits. There were all sorts of Category D and X medications prescribed, mostly by neurologists, dermatologists, and hematologist-oncologists. The five most common were to...
Source: New Harvard Health Information - Category: Consumer Health News Authors: Tags: Children's Health Drugs and Supplements Family Planning and Pregnancy Parenting Source Type: news

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Conclusion: Severe acute pancreatitis during pregnancy leads to a high rate of fetal mortality.Gestational trimester, delayed diagnosis, HTG, MOF, gestational diabetes mellitus, and preeclampsia are predictors of fetal loss. Therefore, close monitoring is essential for pregnancies complicated with HTG, diabetes mellitus, and hypertension. PMID: 32249649 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
DiscussionThis protocol extends to the first years of schooling age the evaluation of the neurotoxicant effect of Mercury and of the other heavy metals on children's neurodevelopment, adjusting for the potential confounders such as the lifestyles and the social economic status of children's families. Longitudinal analysis of neurodevelopment, assessed in different ages (18, 40 months and 7 years), are performed. PMID: 32249266 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
(Frontiers) Pregnant women who deliver early are more likely to have a varied vaginal microbiome, especially in their first trimester. Combining data from several studies, the researchers analyzed information across a wide range of women in terms of ethnicity and stage of pregnancy and also highlight the specific bacteria associated with premature births. The authors hope these findings could help identify women at higher risk of giving birth prematurely.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
This study aimed to investigate methotrexate (MTX)-related toxicity in patients with rheumatoid arthritis (RA) and renal dysfunction. This retrospective cohort study included patients with RA and renal dysfunction. Renal dysfunction was defined as an estimated glomerular filtration rate (eGFR) of  
Source: Rheumatology International - Category: Rheumatology Source Type: research
We report a case of a 39-yr-old woman who developed abnormal uterine bleeding 44 mo after her last recognized pregnancy. An endometrial curettage specimen demonstrated an APSN with some features concerning for an intermediate trophoblastic tumor. A hysterectomy specimen demonstrated residual APSN with foci consistent with emerging PSTT and ETT. This case illustrates the earliest form of PSTT and ETT arising in association with an APSN and supports interpretation of APSN as an intermediary lesion between typical PSN and intermediate trophoblastic tumors.
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: PATHOLOGY OF THE CORPUS: CASE REPORTS Source Type: research
Publication date: Available online 8 November 2019Source: Reproductive ToxicologyAuthor(s): Nis Brix, Lea L.B. Lauridsen, Andreas Ernst, Jørn Olsen, Tine B. Henriksen, Cecilia H. Ramlau-HansenAbstractWe explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000–2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012–2018. Information on maternal ...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Author Affiliations open 1Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA 2Social &Scientific Systems, Inc., Durham, North Carolina, USA 3Westat, Durham, North Carolina, USA 4Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway 5Biostatistics and Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA PDF Version (548 KB) Abstract About This Article Supplemental Material Bac...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
DiscussionPolycystic ovary syndrome (PCOS) affects 6-8% of reproductive-age women making it the most common endocrinopathy in this age group. There is no consensus on the specific diagnostic criteria for PCOS in adolescents as many of the characteristics overlap with normal adolescent physiology. However, patients should have evidence of hyperandrogenism, oligo- or amenorrhea, and potentially polycystic ovaries. PCOS has a genetic component although a specific gene has not been identified. Incidence of PCOS is 20-40% for a woman with a family history. Hyperandrogenism Androgen levels change during puberty therefore actual ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
By: Kimberly Jordan Allen If you experience chronic breakouts medication, isn't the only option. These natural solutions will help alleviate symptoms and address causes of the condition. In the U.S., millions of men and women struggle with acne breakouts. A study from the American Academy of Dermatology found that acne affects more than 50 percent of women between the ages of 20-29, and more than 25 percent of women between the ages of 40-49. The study also surmised that, compared to men, a disproportionate number of adult women are affected. The skin is our largest organ, impacted by various factors, including lifestyl...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Conclusion Any death in a child or teenager is devastating for friends and family, but suicide is perhaps especially hard to bear. Thankfully, it is uncommon – young people are less likely to take their lives than older people. There are about 4.4 deaths for every 100,000 people among 15 to 19-year-olds, compared with 15.1 for every 100,000 people aged 40 to 44. However, because young people are also less likely to die of other causes, suicide among young people is a leading cause of death in this age group. Better understanding of the stresses that can lead to suicide are crucial for helping avert these death...
Source: NHS News Feed - Category: Consumer Health News Tags: Mental health Pregnancy/child Source Type: news
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