Distinct mechanisms for DNA cleavage by myoglobin with a designed heme active center.

This study provides valuable insights into the distinct mechanisms for DNA cleavage by heme proteins, and lays down a base for creating artificial DNA endonucleases by rational design of heme proteins. Moreover, this study suggests that the diverse functions of heme proteins can be fine-tuned by rational design of the heme active center with a hydrogen-bonding network.
PMID: 26775281 [PubMed - as supplied by publisher]

Source: Journal of Inorganic Biochemistry - January 11, 2016 Category: Biochemistry Authors: Zhao Y, Du KJ, Gao SQ, He B, Wen GB, Tan X, Lin YW Tags: J Inorg Biochem Source Type: research