Amyloid imaging using fluorine-19 magnetic resonance imaging ((19)F-MRI).

Amyloid imaging using fluorine-19 magnetic resonance imaging ((19)F-MRI).
Ageing Res Rev. 2016 Jan 6;
Authors: Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S
Abstract
The formation of senile plaques followed by the deposition of amyloid-β is the earliest pathological change in Alzheimer's disease. Thus, the detection of senile plaques remains the most important early diagnostic indicator of Alzheimer's disease. Amyloid imaging is a noninvasive technique for visualizing senile plaques in the brains of Alzheimer's patients using positron emission tomography (PET) or magnetic resonance imaging (MRI). Fluorine-19 ((19)F) displays an intense nuclear magnetic resonance signal and is almost non-existent in the body, targets are detected with a higher signal-to-noise ratio using appropriate fluorinated contrast agents. The recent introduction of high-field MRI allows us to detect amyloid depositions in the brain of living mouse using (19)F-MRI. So far, at least three probes have been reported to detect amyloid deposition in the brain of transgenic mouse models of Alzheimer's disease; (E, E)-1-fluoro-2, 5-bis-(3-hydroxycarbonyl- 4-hydroxy)styrylbenzene (FSB), 1,7-Bis(4'-hydroxy-3'-trifluoromethoxyphenyl)- 4-methoxycarbonylethyl-1,6- heptadiene-3,5-dione (FMeC1) and 6-(3',6',9',15',18',21'- heptaoxa-23',23',23'-trifluorotricosanyloxy)- 2-(4'-dimethylaminostyryl) benzoxazole (XP7). T...

Source: Ageing Research Reviews - January 6, 2016 Category: Genetics & Stem Cells Authors: Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S Tags: Ageing Res Rev Source Type: research