Hsp90 inhibitor celastrol reinstates growth plate angiogenesis in thiram-induced tibial dyschondroplasia.

In conclusion, administering celastrol to dyschondroplastic chicks prevented un-vascularized growth plate, lameness and reinstated angiogenesis. Celastrol may be efficacious for the treatment of TD through the inhibition of Hsp90 expression and limiting the liver damage caused by thiram in broiler chickens. PMID: 26760966 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26760966?dopt=Abstract

Source: Avian Pathology - January 13, 2016 Category: Pathology Authors: Nabi F, Muhammad S, Liu J, Li K, Han Z, Zhang D, Iqbal MK, Li J Tags: Avian Pathol Source Type: research