Induction of Angiogenesis by a Type III Phosphodiesterase Inhibitor, Cilostazol, Through Activation of Peroxisome Proliferator-Activated Receptor-γ and cAMP Pathways in Vascular Cells.

CONCLUSIONS: Our data suggest that the favorable effects of cilostazol on ischemic leg might be through the angiogenesis through the induction of HGF via peroxisome proliferator-activated receptor-γ and cAMP pathways. PMID: 26769045 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26769045?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 14, 2016 Category: Cardiology Authors: Sanada F, Kanbara Y, Taniyama Y, Otsu R, Carracedo M, Ikeda-Iwabu Y, Muratsu J, Sugimoto K, Yamamoto K, Rakugi H, Morishita R Tags: Arterioscler Thromb Vasc Biol Source Type: research