Considerations for Living Kidney Donation Among Women of Childbearing Age: Evidence from Recent Studies

Abstract Each year, approximately 16,000 women become living kidney donors worldwide, donating a kidney to a spouse, family member, or friend. A common concern of women with childbearing potential is whether donation will affect future pregnancy outcomes. The first studies to examine pregnancy outcomes after living kidney donation were mostly reassuring; however, the two largest reported an increased risk of gestational hypertension and preeclampsia in groups of women with pregnancies after donation compared with groups of women with pregnancies before donation. A concern for donation-related risk was recently confirmed in an 11-year cohort study of 85 female donors and 510 healthy non-donors who were carefully matched on baseline risk factors. Donors were 2.4 times more likely to be diagnosed with gestational hypertension or preeclampsia (95 % CI 1.2 to 5.0) compared with healthy non-donors (the combined incidence was 11.5 vs. 4.8 %, respectively). Most donor pregnancies, however, were uncomplicated, with no increased risk for pre-term birth, low birth weight, or Caesarian section and no maternal or neonatal deaths. Importantly, black women were not represented in the three major studies to date, and future research should examine whether risk differs across donor subgroups. As well, a better understanding is needed of the clinical sequelae of gestational hypertension and preeclampsia, including long-term renal outcomes. Based on current evidence, we belie...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Abstract Objective To assess maternal and perinatal outcomes in pregnancies after kidney transplantation in a tertiary center in Brazil. Methods Retrospective cohort of pregnancies in women with kidney transplantation at the Universidade Estadual de Campinas, from January 1995 until December 2017. Medical charts were reviewed, andmaternal and perinatal outcomes were described as means and frequencies. Renal function and blood pressure were evaluated during pregnancy and postpartum. Results A total of 22 women had at least 1 pregnancy during the considered timeinterval, and 3 of them had> 1 pregnancy, totalizing 25 pregn...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
I seem to have lost track of advancements in dipstick technology understanding that it is well established in such areas as pregnancy testing. Home glucose testing for diabetics, of course, is growing increasingly sophisticated with the test strips beingread by a meter. A recent article indicated that this meter technology can be replaced by the camera in a smartphone for recording and analyzing dipstick color changes when screening for kidney disease (see:FDA approves smartphone camera –based dipstick product). Below is an excerpt from the article: Healthy.io, based in Tel Aviv, Israel, has obtained U...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Clinical Lab Industry News Clinical Lab Testing Diagnostics Food and Drug Administration Healthcare Information Technology Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Medical Research Poi Source Type: blogs
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls.MethodsFifty ‐nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1:4 by age (within 2 years) and race to women with two kidneys using data from an integrated healthcare delivery s ystem. Adverse pregnancy outcomes were defined as preterm delivery (delivery 3 days, infant death/transfer to acute facility and low birth weight (
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
CONCLUSIONS:Clinical and molecular characterization of the first 5 Hungarian cases with ADAMTS13 mutations was presented. Compound heterozygous, damaging ADAMTS13 mutations with deficient plasma ADAMTS13 activity were associated with serious clinical consequences. In case of thrombotic microangiopathy in young patients with stroke, or HELLP syndrome, complete workup for ADAMTS13 activity and inhibitors is necessary, and genetic analysis should be considered. Three new ADAMTS13 mutations (c.1016_1017delCA, c.3199T>A , c.2839C>T) were identified and shown to be associated with decreased plasma ADAMTS13 activity.Disclos...
Source: Blood - Category: Hematology Authors: Tags: 311. Disorders of Platelet Number or Function Source Type: research
AbstractPurpose of ReviewTo review the studies and practice guidelines on the preeclampsia risks in kidney donors and recipients.Recent FindingsThere is a small increased risk of gestational hypertension and preeclampsia in pregnancies that follow kidney donation. Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline (2017) and the 2015 American Society of Transplantation (AST) consensus conference statement recommends counseling kidney donors about this increased risk. There is no observed increase in fetal complications or eclampsia post-kidney donation. Preeclampsia is more commonly observed in ki...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
AbstractA 29-year-old woman with past medical history of hypertension was referred to our hospital for the evaluation of kidney dysfunction (serum creatinine 1.0  mg/dL), proteinuria (0.54 g/gCre), and microscopic hematuria. Renal biopsy before the first pregnancy was supportive for benign nephrosclerosis with no evidence of vasculitis. After her second pregnancy and delivery when she was 32 years old, she developed proteinuria of 3.2 g/gCre, hematuria, and elevated serum creatinine level of 2.6 mg/dL. Second renal biopsy revealed necrotizing glomerulonephritis and her serum MPO-ANCA was positive, ...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
ABSTRACT Background: Liver transplantation (LT) is a successful treatment for both acute liver failure and end‐stage liver disease. The number of women of reproductive age undergoing LT is increasing. Pregnancy outcomes are favourable but there is still a lack of prognostic markers. We aimed to identify factors predictive of adverse pregnancy outcomes in LT recipients. Methods: An analysis of all pregnancies occurring in LT recipients from 1989‐2016 at King's College Hospital was performed. Clinical data of 162 conceptions in 93 women was reviewed. Descriptive and regression analyses were done to examine associations b...
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
ConclusionsPregnancy in HTx carries high cardiometabolic complications and decreased kidney function, but is feasible with acceptable outcomes and no impact on mother's survival.This article is protected by copyright. All rights reserved.
Source: Transplant International - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Chronic kidney disease aff ects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus off ering an opportunity to refl ect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% of the world's ...
Source: Journal of Hypertension - Category: Cardiology Tags: News Source Type: research
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