Characterization of carbapenem-resistant Acinetobacter calcoaceticus-baumannii complex‎‏ isolates from nosocomial bloodstream infections in southern Iran.

Characterization of carbapenem-resistant Acinetobacter calcoaceticus-baumannii complex‎‏ isolates from nosocomial bloodstream infections in southern Iran. J Med Microbiol. 2016 Jan 8; Authors: Pourabbas B, Firouzi R, Pouladfar G Abstract A. baumannii is an important opportunistic bacterial pathogen responsible for serious infections in hospitalized patients. From a total of 78 consecutive non-repetitive Acinetobacter spp. isolates from patients with blood infections, 61 were carbapenem resistant which were positive for blaOXA-51-like (96.7%), blaOXA-23-like (77%), blaOXA-58-like (8.1%), and blaOXA-40-like (32.8%) by multiplex PCR. The isolates were identified as A. baumannii (n=59), and A. nosocomialis (n=2). Also, we found a case of A. junii causing bacteraemia, that possesses IMP. High levels of resistance were observed to fluoroquinolones, aminoglycosides, tigecycline and to the beta-lactam antibiotics, including piperacillin/tazobactam and ampicillin/sulbactam. ISAba1 was present in 96.7% of all Acb isolates. Also, 33(54.1%) and 23(37.7%) isolates were harboring the ISAba1 upstream of blaOXA-23-like and blaOXA-51-like genes, respectively, though not observed in A. nosocomialis isolates. No relationship was observed between the presence of the ISAba1 upstream oxacillinase genes and the level of carbapenem resistance in all Acb isolates. Only 2 genes encoding metallo-beta-lactamase (VIM, SPM) were detected in all Acb isolates. ...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research