Solanum nigrum Leaf: Natural Food Against Diabetes and its Bioactive Compounds

In the present study, antidiabetic activity of the leaf extract of Solanum nigrum (SN), a traditional edible plant was investigated in streptozotocin-induced diabetic rats. Novel microwave extraction method was used to get more activity and bioactive compound. The SN leaf extract indicated significant inhibition for glucose diffusion and also for other pancreatic enzymes such as α- amylase (IC50-39±0.06 μg mL–1) and α-glucosidase (IC50-78.8±0.7 μg mL–1). The antidiabetic activity of the SN leaf extract (125, 250 and 375 mg kg–1) was investigated in streptozotocin-induced diabetic rats. The oral administration of leaf extract (375 mg kg–1) significantly decreased hyperglycemia, urine sugar level, total cholesterol and triglycerides. It also reduced and increased water and food intake respectively. Furthermore, it had an effect on increased kidney function, which reflected in decreased urine output and urine sugar compared to diabetic. Solanum nigrum contained polyphenols (14.72±0.37% GAE) and major bioactive molecules such as p-coumaric acid, quercitin, catechol, caffeic acid, gallic acid and protocatechuic acid was analyzed by High Performance Liquid Chromatography (HPLC) and its beneficial effects on diabetic status were evaluated. The results demonstrate the beneficial effect of the SN leaf extract as functional food or as adjuvant in streamlining diabetes by consuming as daily or frequent intake in the form of natura...
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research