Phytochemical Screening, Anti-Inflammatory and Analgesic Activities Of Formulation Cream of Silene vulgaris

The present study evaluates the anti-inflammatory and analgesic activities of cream formulation of Silene vulgaris leaves in rats. The anti-inflammatory effect of cream of Silene vulgaris at doses of 10 and 20% applied topically and was evaluated in rats during 6 h using the acute anti-inflammatory model of carrageenan-induced paw edema and during 7 days by chronic anti-inflammatory activity of cotton pellet induced granuloma. The analgesic activity using two in vivo models: acetic acid-induced writhing test and plantar test (Hargreaves method) was also studied. Furthermore, the acute toxicity of topical cream was evaluated in rats. Finally, a phytochemical analysis of Silene vulgaris was performed. The resulted demonstrated a significant reduction of inflammation after carrageenan-induced rat paw edema in treated group with cream of S. vulgaris at 20% compared to Diclofenac (85.71 and 58.33%, respectively). Furthermore, a significant reduction of granuloma weight of cotton pellet was noted in treated group with S. vulgaris cream compared to control (1.96±0.04, 2.59±0.2, respectively) with an ED50 of 17.2. In analgesic test, the number of writhings induced by acetic acid solution was decreased by 35.5±1.77 in treated group with cream of Silene vulgaris at 20%. A potential peripheral analgesia on acetic acid-induced writhing and also in the plantar test was observed. In addition, topical application of cream did not produce any mortality and any visibl...
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research