Abstract A29: Frequency and circadian timing of eating may influence metabolic risk of breast cancer

We examined the associations of eating frequency and timing with metabolic and inflammatory biomarkers putatively associated with breast cancer risk. We used data from a nationally representative sample of adult women participating in the National Health and Nutrition Examination 2009-2010 Survey.Eating frequency and timing variables were calculated from 24-hour food records and included (1) proportion of calories consumed in the evening (between 17.00-00.00h), (2) nighttime fasting duration, and (3) number of eating episodes per day. Multivariable linear regression models examined each eating frequency and timing exposure variable with hsCRP concentrations and the homeostatic model assessment of insulin resistance (HOMA-IR). Logistic regression modeled associations of these same exposure variables with odds of elevated hsCRP (defined as≥ 1.0 mg/L). Models were adjusted for age, education, race/ethnicity, BMI, sleep duration, and caloric intake. Sample weights were used to account for differential probabilities of selection into the sample, nonresponse, and noncoverage. Standard errors were estimated using Taylor Series Linearization.Dietary, anthropometric and high-sensitivity C-reactive protein (hsCRP) data were available for 2,212 women, and fasting glucose and insulin concentrations (i.e., HOMA-IR) were available for 1,066 women. The mean age of women in this sample was 46.8 (SEM=0.66) years. They consumed an average of 43.1% (SEM=0.62) of daily energy intake between 1...
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Cancer Metabolic Pathways: Poster Presentations - Proffered Abstracts Source Type: research