Abstract A25: Tumor metabolism as a driver of lethal prostate cancer

Conclusions: In this large prostate cancer study, we demonstrate alterations in key metabolic pathways within the prostate during carcinogenesis, and offer evidence that these changes differ in lethal compared to non-lethal tumors. We additionally identify novel associations with the expression of certain metabolic genes. There was no evidence for a strong role of the tumor microenvironment in this study. Our results were robust to confounding and independent of Gleason grade. A better comprehension of the dysregulation in the genes and pathways involved in lethality may offer novel therapeutic targets for the treatment of prostate cancer.Citation Format: Rachel S. Kelly, Jennifer A. Sinnott, Jennifer R. Rider, Ericka Ebot, Travis Gerke, Kathryn L. Penney, Michaela Bowden, Andreas Pettersson, Massimo Loda, Meir Stampfer, Philip Kantoff, Neil E. Martin, Edward L. Giovannucci, Svitlana Tyekucheva, Matthew Vander Heiden, Lorelei A. Mucci. Tumor metabolism as a driver of lethal prostate cancer. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr A25.

Source: Molecular Cancer Research - January 15, 2016 Category: Cancer & Oncology Authors: Kelly, R. S., Sinnott, J. A., Rider, J. R., Ebot, E., Gerke, T., Penney, K. L., Bowden, M., Pettersson, A., Loda, M., Stampfer, M., Kantoff, P., Martin, N. E., Giovannucci, E. L., Tyekucheva, S., Heiden, M. V., Mucci, L. A. Tags: Cancer Metabolic Pathways: Poster Presentations - Proffered Abstracts Source Type: research