Abstract B19: LKB1-AMPK axis regulates the switch of Pyruvate Kinase M isoforms to tolerate nutritional stress

Conclusion: The study highlights the integral role of LKB1-AMPK axis in dynamically regulating the preferential expression of either PKM2 or PKM1 in response to nutritional status in lung cancer and breast cancer cell line models, drawing an inference with regard to real life tumor microenvironment.Citation Format: Gopinath Prakasam, Rameshwar N.K. Bamezai. LKB1-AMPK axis regulates the switch of Pyruvate Kinase M isoforms to tolerate nutritional stress. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr B19.
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Signaling Pathways and Cancer Metabolism: Poster Presentations - Proffered Abstracts Source Type: research