Abstract A10: SLC7A11 contributes to the pathogenesis of lung cancer

Conclusion: Our results demonstrate that xCT is highly expressed in a subset of NSCLCs. The induction of xCT in transformed aiway epithelial cells causes tumor formation in nude mice. The mechanism of malignant transformation involves the Warburg effect. Further investigation into the mechanisms of transformation may help in answering fundamental questions pertaining to how glutamate/cystine exchange contributes to lung cancer development and progression and also in establishing xCT as a potential novel therapeutic target in lung cancer.Citation Format: Xiangming Ji Ji, Jun Qian, Jamshedur Rahman, Brad Harris, Megan Hoeksema, Heidi Chen, Rosana Eisenberg, Jamey Young. SLC7A11 contributes to the pathogenesis of lung cancer. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr A10.

Source: Molecular Cancer Research - January 15, 2016 Category: Cancer & Oncology Authors: Ji, X. J., Qian, J., Rahman, J., Harris, B., Hoeksema, M., Chen, H., Eisenberg, R., Young, J. Tags: Cancer Metabolic Pathways: Poster Presentations - Proffered Abstracts Source Type: research