Systematic review of the association between chronic social stress and telomere length: A life course perspective.

Systematic review of the association between chronic social stress and telomere length: A life course perspective.
Ageing Res Rev. 2015 Dec 28;26:37-52
Authors: Oliveira BS, Zunzunegui MV, Quinlan J, Fahmi H, Tu MT, Guerra RO
Abstract
Our aim was to examine whether chronic social stress is associated with telomere length throughout the life course, following our protocol published in 2014. Structured searches were conducted in MEDLINE (PubMed interface), EMBASE (OVID interface), Cochrane Central (OVID interface) and grey from their start date onwards. Reference lists of retrieved citations were hand searched for relevant studies. Eighteen studies published until May 1, 2015 investigating the association between chronic social stress (as defined by poverty, exposure to violence, or family caregiving) and telomere length in healthy or diseased adults and children were independently selected by 2 reviewers. Sixteen of those studies were cross-sectional and two had a longitudinal design. Studies differed in type of stress exposure, method to measure telomere length and cell type. As meta-analysis could not be conducted, the data were synthesized as a narrative review. Based on this comprehensive review, chronic social stress accompanies telomere shortening in both early and adult exposures, with most eligible studies showing a significant relationship. We discuss the significance of chronic stress of social origin and the potential for s...

Source: Ageing Research Reviews - December 28, 2015 Category: Genetics & Stem Cells Authors: Oliveira BS, Zunzunegui MV, Quinlan J, Fahmi H, Tu MT, Guerra RO Tags: Ageing Res Rev Source Type: research