The Next Big Short

Mike Burry, the hedge fund manager featured in the movie The Big Short, anticipated the housing crash by reading loan documents. Similarly, those in the food and agriculture arena predict a massive shift in farming practices by studying the inimical effects of the widely used weedkiller, RoundUp®. Glyphosate (the main ingredient in RoundUp®) has been under fire lately for its effects on human health. In March 2015, 17 experts from 11 countries analyzed the effect of glyphosate at the International Agency for Research on Cancer (IARC) and deemed it a probable carcinogen. It's important to note that the USA uses 20% of the world's RoundUp® yet only comprises 5% of the world's population. As a result of the World Health Organisation's (WHO) announcement that glyphosate is a probable carcinogen, many law firms are opening class action suits against billion dollar chemical industry leaders.(1,2,3,4,5) Matthew Philips, a Las Vegas attorney, is suing Monsanto for false advertising. The filing papers state, "Defendant makes the claim that Roundup®, the world's most popular weedkiller, works by targeting an enzyme supposedly found only in plants, but not in people. And this is blatantly false." The reason it's false is that, as a registered antibiotic, glyphosate kills essential gut bacteria. Without these bacteria, humans cannot manufacture enzymes that produce seratonin and dopamine, the feel-good chemicals. Glyphosate also disrupts our ability to absorb es...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Publication date: Available online 22 February 2019Source: SteroidsAuthor(s): Hye Joung Choi, Bao Ting ZhuAbstract2-Methoxyestradiol is an endogenous nonpolar metabolite of 17β-estradiol with a strong antitubulin activity. Earlier we showed that 2-methoxyestradiol increases the level and activity of cyclin B1/CDK1, which subsequently induces mitotic prometaphase arrest. In the present study, we demonstrate that upregulation of cyclin B1/CDK1 is responsible for the increased phosphorylation of the anti-apoptotic proteins Bcl-2 and Bcl-XL in 2-methoxyestradiol-induced, mitotically-arrested cancer cells. Additional analy...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
This study suggests that the U11-DOX/CUR NPs have promising potential for combination treatment of lung cancer.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In this study, we developed two kinds of Y-shaped double-stranded DNA nanostructures (Y-DNAs), including a single unit composed of three DNA strands (YS-DNA) and a ligated multiunit complex formed by crosslinking each YS-DNA (YL-DNA), and investigated whether they have immunostimulatory activity in innate immune cells. YS-DNA and YL-DNA induced the production of immune cytokines such as IL-12 and TNF-α and the expression of costimulatory molecules such as CD80 and CD86 in primary mouse dendritic cells and macrophage cells (RAW264.7 cells). A Coprecipitation study demonstrated that YL-DNA was directly associated with ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2019Source: Biomedicine &Pharmacotherapy, Volume 112Author(s): Sharvil Patil, Vinayak Ujalambkar, Atul Rathore, Supada Rojatkar, Varsha PokharkarAbstractGalangin possess wide range of pharmacological activities including antiarthritic, hepatoprotective, anti-inflammatory, antibacterial, and anticancer especially in hepatocellular carcinoma. However, its biological use has been limited owing to its poor aqueous solubility, P-gp efflux and rapid in vivo metabolism by cytochrome enzymes. In order to address the drawbacks of galangin, the current work was designed with an objective to prepare liver ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
This study was aimed to investigate the anti-oxidative and the ameliorative effects of Antrodia cinnamomea ethanol extract (ACEE) on reproduction dysfunction in male diabetic rats. The diabetic condition was induced by administrating the combination of streptozotocin (STZ) (65 mg/kg) and nicotinamide (NA) (230 mg/kg). Three different doses of ACEE were tested (385, 770, 1540 mg/kg) for 5 weeks. The results indicated that the ACEE improved STZ-NA induced hyperglycemia, oxidative stress, and insulin resistance. In addition to this, ACEE reduced the degree of lipid peroxidation, recovered the abnormal str...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2019Source: Biomedicine &Pharmacotherapy, Volume 112Author(s): Meiqi Zhao, Manyu Luo, Yueqing Xie, Hua Jiang, Cedric Cagliero, Ninghuan Li, Hao Ye, Mingyuan Wu, Shuai Hao, Tianyuan Sun, Hui Yang, Mengxiao Zhang, Tong Lin, Huili Lu, Jianwei ZhuAbstractRecombinant human interleukin-15 (IL-15) is a potent cancer immunotherapeutic candidate due to its excellent immune stimulating effects. Previous work demonstrated that IL-15 appeared with short half-life in circulation system, while the complex with its receptor can prolong the half-life as well as benefit its activities in vivo. Therefore, IL-15 c...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In conclusion, we have verified that circVAPA is up-regulated in CRC patients’ tissues and plasma, and exerts oncogenic properties by sponging miR-101 in CRC. CircVAPA could serve as a promising biomarker and a therapeutic target for CRC.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2019Source: Biomedicine &Pharmacotherapy, Volume 112Author(s): Bing Wu, Heyuan Wang, Lenign Zhang, Chenglin Sun, Hang Li, Chunyan Jiang, Xiaodong LiuAbstractAs a key regulator of DNA translesion synthesis (TLS) pathway, RAD18 is reported to be abnormally expressed in many kinds of cancers. In glioma, RAD18 was overexpressed in the primary and recurrent glioblastoma multiforme specimens, and its overexpression weakened ionizing radiation-induced apoptosis in glioma A172 cells. Moreover, A172 cells with mutational P53 also showed enhanced radiation resistance. And RAD18 activation induced by cycli...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2019Source: Biomedicine &Pharmacotherapy, Volume 112Author(s): Lauren Tomlinson, Zhen Qi Lu, Robert A Bentley, Helen E. Colley, Craig Murdoch, Steven D. Webb, Michael J. Cross, Ian M. Copple, Parveen SharmaAbstractDose-dependent cardiotoxicity is the leading adverse reaction seen in cancer patients treated with doxorubicin. Currently, dexrazoxane is the only approved drug that can partially protect against this toxicity in patients, however, its administration is restricted to those patients receiving a high cumulative dose of anthracyclines. Investigations into the mechanisms of cardiotoxicity ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2019Source: Biomedicine &Pharmacotherapy, Volume 112Author(s): Jaturon Kwanthongdee, Chotchanit Sunrat, Bamroong Munyoo, Patoomratana Tuchinda, Napason Chabang, Witchuda SaengsawangAbstractGlioblastoma is the most common and the most malignant form of brain tumor. This devastating tumor results in death within a year after diagnosis. Although the tumor mass can be surgically removed, glioma cells invade other areas in the brain leading to tumor recurrence and poor prognosis. Therefore, new agents that can overcome cancer cell invasion are urgently required. Phyllanthus taxodiifolius Beille (P. t...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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