Everything You Wanted To Know About Microdosing (But Were Afraid To Ask)
Long before microdosing was being touted as the Silicon Valley life hack du jour, Dr. James Fadiman was investigating the potential mind-enhancing effects of ingesting psychedelic drugs like LSD and psilocybin, more commonly known as magic mushrooms. In the 1960s, Fadiman conducted pioneering psychedelic research, including one study in which he gave LSD and another hallucinogen, Mescaline, to scientists, mathematicians and architects to see how it affected creative problem-solving. (His research was one of the last investigations into LSD due to the Food and Drug Administration's mid-1960s research ban of the substance.) More recently, Fadiman authored "The Psychedelic Explorer's Guide," a how-to manual for safe and therapeutic psychedelic drug experiences. Now, his research has taken a new turn. Fadiman is examining the effects of administering psychedelic drugs like LSD and psilocybin in amounts so small that they are below the perceptual threshold. As part of an ongoing research project, Fadiman is collecting the self-reported testimonies of hundreds of people from around the globe who have experimented with psychedelic "microdosing" to treat ailments from anxiety to attention deficit hyperactivity disorder, or simply to improve productivity or break through writer's block. How does one microdose? You take a very small dose of either LSD or psilocybin (roughly one-tenth to one-fifth of a normal dose), on...
Authors: Cetintas S, Tezcan G, Tunca B, Egeli U, Gokgoz MS, Cecener G Abstract Distant organ tumor dissemination is a major cause of breast cancer-related deaths. In 2010, we analyzed the prognostic importance of the circulating tumor markers (CTM) cytokeratin (CK)19, CK20, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) in relation to the clinical and pathological characteristics of patients with breast cancer (BC). To assess the clinical utility of CK19, CK20 and EGFR in predicting distant metastasis and recurrence in BC, here we report 7-year follow-up results of 77 pa...
This article provides an overview of currently available relevant real world data sources and the utilization potential. It lists exemplary results of existing studies: secondary data analyses based on billing data from statutory health insurance funds were used among other things to estimate the participation rate in the statutory skin cancer screening. This was approximately 31% in the 2‑year period and was higher in the western German federal states than in the eastern ones. Furthermore, participation was higher for women than for men. Regional data in combination with sociostructural and sociodemographic indicators a...
CONCLUSIONS: TRKA expression can be found in 1.6% of solid tumours and can be paralleled by NTRK1 gene rearrangements or mostly GCN gain. The prognostic and translational therapeutic impact of the latter remains to be established. PMID: 29802225 [PubMed - indexed for MEDLINE]
This study is based on 5,174 men aged 50-66 years, who in 1995-1996 participated in the first round of the Göteborg randomized screening trial (initial T-PSA level
Authors: Chao PC, Chang CC, Chang HA Abstract Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been increasingly used to treat bipolar depression. Researchers recently noticed the risk of tDCS-emergent mania/hypomania in depressed patients and started to evaluate this risk by launching a meta-analysis. Here we present a female with bipolar II depression who rapidly developed hypomanic switching during bifrontal tDCS. PMID: 30235920 [PubMed]
CONCLUSION: These findings support potential mechanism of delayed recovery after circadian disruption in bipolar animal model could be an alteration of relative PKC activities among mood regulation related brain regions. It is required to investigate the PKC downstream signaling related to the delayed recovery pattern. PMID: 30235919 [PubMed]
CONCLUSION: Adiposity may have primed the carcinogenic potential, leading to lorazepam-associated carcinogenesis in overweight patients. Epidemiological studies addressing this issue should consider the potential modulator contributing to benzodiazepine-associated carcinogenesis. PMID: 30235918 [PubMed]
CONCLUSION: The specific central and peripheral metabolites were associated with psychological disorders including depression, anxiety, suicidal ideation and anger in CRPS patients, showing pathological interactions between a painful body and mind. PMID: 30235917 [PubMed]
CONCLUSION: This study helps identify the specific interaction surfaces involved in the pathologic phenotype of TR mutants and TRIAC as a possible therapeutic agent for patients suffering from RTH syndromes. PMID: 30235988 [PubMed - as supplied by publisher]
CONCLUSIONS: At a high-volume center, gasless transaxillary endoscopic thyroid surgery done with robotic assistance was a safe, efficient and effective approach in a diverse North American patient population. PMID: 30235982 [PubMed - as supplied by publisher]
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