CCC Update 014

Updates to the CCC seem to be coming thick and fast these days. Keep the feedback coming on this free guide to Critical Care encompassing over 1650 pages. This is what has sprung up since CCC Update 013: Mitchondrial dysfunction and mitochondrial diseases About 1.5 billion years ago something extremely odd and extremely pivotal happened in our evolution. One cell enveloped another in an endosymbiotic union. The mitochondria were born, and they continue to be passed along by our mothers today. As the energy powerhouses of our cells, it makes sense that if they don’t work, then we are in big trouble. This manifests as various genetic mitochondrial diseases, which are outlined on this page of the CCC. However, another intriguing hypothesis – one espoused by Mervyn Singer among others – is that mitochondrial dysfunction is central to the sine qua non of critical illness, multi-organ dysfunction syndrome (MODS). This page reviews the structure and function of mitochondria in clinically relevant terms, the effects of systemic inflammation on mitochondrial function and the rationale for a mitochondrial explanation for MODS. Preoxygenation Though commonplace, denitrogenating the lungs to create an oxygen reservoir prior to intubation is a nifty trick. This page has been throughly rejigged with more info on reasons for preoxygenation failure and extended summaries of different devices for preoxygenation. Apnoeic oxygenation The major update is my take on the FE...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Critical Care Compendium Education apnoeic oxygenation Delayed Sequence Intubation initial management of severe sepsis and septic shock mitchondrondrial dysfunction neutropaenic sepsis preoxygenation sepsis overview septic cardiomyopathy Source Type: blogs