TGen study targets SGEF protein in treating glioblastoma brain tumors

(The Translational Genomics Research Institute) The Translational Genomics Research Institute (TGen) has identified a protein called SGEF that promotes the survival of glioblastoma tumor cells and helps the cancer invade brain tissue. TGen researchers identified SGEF as a target for new brain cancer therapies in a study published today by Molecular Cancer Research, a journal of the American Association for Cancer Research, the world's largest professional organization dedicated to advancing cancer research.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Catherine SEVA Glioblastoma (GBM) is the most lethal primary brain tumor in adults and is known to be particularly aggressive and resistant to anti-cancer therapies, mainly due to the presence of GBM stem cells (GBMSC). By in vitro approaches supported by analysis from patients’ databases, we determined how α6-integrin and Fibroblast Growth Factor Receptor 1 (FGFR1) work in concert to regulate proliferation and stemness of GBMSC. We showed that α6-integrin regulates the expression of FGFR1 and its target gene Fokhead Box M1 (FOXM1) via the ZEB1/YAP1 transcription complex. These results we...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Ni W, Luo L, Zuo P, Li R, Xu X, Wen F, Hu D Abstract Glioma is a commonly diagnosed brain tumor that show high mortality rate. Despite the great advancement of cancer therapy in recent years, chemotherapy is still an important approach for treatment of glioma. However, long-term chemotherapy usually causes serious side-effects or complications. We are supposed to take strategies to enhance the efficacy of current chemotherapy. In the present study, we observed obvious upregulation of miR-374a in glioma cells. More importantly, we found that knockdown of miR-374a was able to enhance the etoposide-induced cy...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
by Gertrud Rey Although cancer therapies have improved dramatically in recent years, the main options for treating cancer still consist of surgery, chemotherapy, and radiation therapy. This limitation is a problem for aggressive cancers like glioblastoma multiforme (GBM), brain cancers which are typically resistant to traditional therapies. GBM is a high grade glioma, an aggressive […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Gertrud Rey Information glioblastoma multiforme herpes simplex virus viral viral oncotherapy viruses Source Type: blogs
Funding Opportunity PAR-19-194 from the NIH Guide for Grants and Contracts. The overall purpose of this funding opportunity announcement (FOA) is to stimulate the development of novel microbial-based cancer therapies, especially for conditions where conventional cancer therapies are inadequate, such as poorly vascularized, hypoxic, solid tumors, dormant or slowly dividing cells resistant to current interventions, and brain tumors. Utilizing bacteria, archaebacteria, bacteriophages and other non-virus microorganisms, this initiative will support research projects designed to study the underlying mechanisms of the complex i...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Funding Opportunity PAR-19-193 from the NIH Guide for Grants and Contracts. The overall purpose of this funding opportunity announcement (FOA) is to stimulate the development of novel microbial-based cancer therapies, especially for conditions where conventional cancer therapies are inadequate, such as poorly vascularized, hypoxic, solid tumors, dormant or slowly dividing cells resistant to current interventions, and brain tumors. Utilizing bacteria, archaebacteria, bacteriophages and other non-virus microorganisms, this initiative will support research projects designed to study the underlying mechanisms of the complex i...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
sand Glioblastoma (GBM) is the most common type of primary brain tumor in adults. Despite recent advances in cancer therapy, including the breakthrough of immunotherapy, the prognosis of GBM patients remains dismal. One of the new promising ways to therapeutically tackle the immunosuppressive GBM microenvironment is the use of engineered viruses that kill tumor cells via direct oncolysis and via stimulation of antitumor immune responses. In this review, we focus on recently published results of phase I/II clinical trials with different oncolytic viruses and the new interesting findings in preclinical models. From synge...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Publication date: Available online 29 January 2019Source: Journal of Theoretical BiologyAuthor(s): Günther K.H. Zupanc, Frederick B. Zupanc, Rifat SipahiAbstractThe neurosphere assay is a powerful in vitro system for studying stem/progenitor-cell-driven tissue growth. By employing a stochastic cellular automata model, we simulated the development of tumorous neurospheres in response to transformation of a randomly selected progenitor cell into a brain tumor stem cell. Simulated tumorous neurospheres were distinguished from normal neurospheres by their size, which exceeded that of normal neurospheres typically manifold...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: Available online 31 December 2018Source: Pathology - Research and PracticeAuthor(s): Aihua Zhu, Xuetao Li, Haibin Wu, Zongning Miao, Fenglai Yuan, Feng Zhang, Bei Wang, Youxin ZhouAbstractGliomas are the most common primary brain malignant tumors in humans. Glioblastoma multiforme(GBM) is the most malignant intracranial tumor with a relatively poor prognosis. There promote us to find effective anti-cancer therapies to reduce cancer mortality. By using bioinformatic analysis, we found SSFA2 as a gene with elevated expression in the glioma tissues. We detected the expression of SSFA2 in glioma tissues and i...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
(Far Eastern Federal University) This risky method of anti-cancer therapy was suggested by scientists of Far Eastern Federal University (FEFU). Their review of mechanisms for molecular activation of stem cells of gliomas (most widely-spread brain tumors) was approved for publishing in the Frontiers in Cellular Neuroscience journal.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
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