Caffeine augments the antidepressant-like activity of mianserin and agomelatine in forced swim and tail suspension tests in mice.

CONCLUSION: The synergistic effect of caffeine and the tested drugs may be associated with their summative actions on monoaminergic neurotransmission. Caffeine-mianserin and caffeine-agomelatine interactions might have been of pharmacodynamic origin.
PMID: 26721352 [PubMed - in process]

Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Poleszak E, Szopa A, Wyska E, Kukuła-Koch W, Serefko A, Wośko S, Bogatko K, Wróbel A, Wlaź P Tags: Pharmacol Rep Source Type: research