Nuclear factor E2-related factor-2 (Nrf2) expression and regulation in male reproductive tract.

CONCLUSIONS: Components of the Nrf2/NRF2 system along with coordinated genes are expressed in testis and epididymis. Moreover, some interspecies differences between rat and human were observed, which may impact extrapolation of experimental data into clinical findings. Studies on animal model showed that corpus of epididymis is the most responsive part of the male reproductive tract to oltipraz exposure at the gene expression level.
PMID: 26721360 [PubMed - in process]

Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Wajda A, Łapczuk J, Grabowska M, Słojewski M, Laszczyńska M, Urasińska E, Droździk M Tags: Pharmacol Rep Source Type: research