ET-1 mediates the release of reactive oxygen species and TNF-α in lung tissue by protein kinase C α and β1.

CONCLUSION: Endothelin-1 induces ROS generation, increases TNF-α level and lung edema via activation of PKC αβ1.
PMID: 26721363 [PubMed - in process]

Source: Pharmacological Reports - January 13, 2016 Category: Drugs & Pharmacology Authors: Gorąca A, Kleniewska P, Skibska B Tags: Pharmacol Rep Source Type: research