Systemic sclerosis-like histopathological features in the myocardium of uPAR-deficient mice
Conclusions
Typical histopathological features of SSc-related cardiomyopathy are mimicked by uPAR-deficient mice. The downregulation of uPAR in the myocardium of patients with SSc may suggest similar underlying pathogenetic mechanisms. uPAR-deficient mice could be used as a preclinical model to study the mechanisms and therapeutic approaches of myocardial involvement in SSc.
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Manetti, M., Rosa, I., Fazi, M., Guiducci, S., Carmeliet, P., Ibba-Manneschi, L., Matucci-Cerinic, M. Tags: Immunology (including allergy), Interstitial lung disease, Connective tissue disease, Clinical diagnostic tests Basic and translational research Source Type: research
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