Systemic sclerosis-like histopathological features in the myocardium of uPAR-deficient mice

Conclusions Typical histopathological features of SSc-related cardiomyopathy are mimicked by uPAR-deficient mice. The downregulation of uPAR in the myocardium of patients with SSc may suggest similar underlying pathogenetic mechanisms. uPAR-deficient mice could be used as a preclinical model to study the mechanisms and therapeutic approaches of myocardial involvement in SSc.
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: Immunology (including allergy), Interstitial lung disease, Connective tissue disease, Clinical diagnostic tests Basic and translational research Source Type: research