7 Thoughts On Today's Pharma & Biotech News

Seven thoughts: Shire’s purchase of Baxalta is emblematic of the shift in the drug industry. The company that popularized Adderall and help market the diagnosis of ADHD is now focused almost entirely on pricey, rare diseases, with an option on cancer. Vertex and Illumina both released relatively weak financial forecasts ahead of the J.P. Morgan Healthcare Conference. This could add to feelings that maybe healthcare investing has peaked, or at least become a realm for stock pickers. Which is exactly what everyone said at this time of year last year. There’s a lot of controversy on Illumina’s creation of a startup, GRAIL, that will aim to develop a screening test for cancer. At this point, you’re either basically betting on the track record of Jay Flatley and venture capitalist Robert Nelsen, or you’re waiting for more info. GRAIL is not competing with the dozens of other “liquid biopsy” companies. None are doing screening, and, as Antonio Regalado at Technology Review pointed out on Twitter yesterday, they can do that because they can use their own DNA sequencing products for cheaper than everyone else. Juno Therapeutics’ acquisition of AbVitro, a company spun out of the lab of Harvard genomics guru George Church, seems smart. The technology sounds like a great way to find new ways to make white blood cells attack cancer, and it’s clever that payments from Juno partner Celgene will help pay for the $100 m...
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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Publication date: Available online 16 July 2019Source: Journal of Advanced ResearchAuthor(s): Laura Botta, Luigino Dal Maso, Stefano Guzzinati, Chiara Panato, Gemma Gatta, Annalisa Trama, Massimo Rugge, Giovanna Tagliabue, Claudia Casella, Bianca Caruso, Maria Michiara, Stefano Ferretti, Flavio Sensi, Rosario Tumino, Federica Toffolutti, Antonio Giampiero Russo, Anna Luisa Caiazzo, Lucia Mangone, Walter Mazzucco, Silvia IacovacciAbstractThe aims of this study were to provide life expectancy (LE) estimates of cancer patients at diagnosis and LE changes over time since diagnosis to describe the impact of cancer during patien...
Source: Journal of Advanced Research - Category: Research Source Type: research
Publication date: Available online 17 July 2019Source: Academic RadiologyAuthor(s): Henkjan Huisman
Source: Academic Radiology - Category: Radiology Source Type: research
ConclusionIt is feasible to use CNN based algorithm to accurately distinguish cancerous regions in OCT images. This fully automated method can overcome limitations of manual interpretation including interobserver variability and speed of interpretation and may enable real-time intraoperative margin assessment.
Source: Academic Radiology - Category: Radiology Source Type: research
In this study, a data processing pipeline for spatially resolved metabolomics analysis of tumor microregion heterogeneity was developed and built into a graphical interface with MSI software. Biological tissue sections were analysed by ambient air-flow assisted desorption electrospray ionization mass spectrometry imaging. Histology-driven and characterized ion images overlay combined with metabolic feature-based spatial segmentation were developed to accurately extract the metabolic profile from the tissue microregion of interest. In addition, appropriate data pretreatment methods were investigated to evaluate their abilit...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract In cancer diagnostics, specific analysis of blood-circulating proteins biomarkers of cancer is often complicated both by their inherently low concentrations and by strong interference from serum/blood proteins. Here, we report a simple and robust electrochemical cellulase-linked sandwich assay on magnetic beads (MBs) for fM-sensitive analysis of the Human Epidermal growth factor Receptor-2 HER-2/neu protein that is over-expressed in most aggressive breast cancers. In the assay, a sandwich is assembled by capturing HER-2/neu on either antibody (Ab) or aptamer-modified MBs accompanied by reaction with the s...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
ConclusionsThe DCE was sensitive to caregivers’ preferences for managing their child's coexisting cognitive/intellectual and emotional/behavior/developmental disability. Findings may help providers gauge treatment in a broader context of health outcomes.
Source: Academic Pediatrics - Category: Pediatrics Source Type: research
Publication date: September 2019Source: Journal of Functional Foods, Volume 60Author(s): Jingwen Xu, Sriram K. Vidyarthi, Weibin Bai, Zhongli PanAbstractRosa roxburghii (R. roxburghii), primarily distributed in southwest region in China, is known for its remarkable high vitamin C, SOD, and flavonoids contents. A diet rich in beneficial antioxidants such as polysaccharides, vitamin C, superoxide dismutase (SOD), and phenolics is associated with reducing risks of chronic diseases. This review examines the chemical composition in fruit of R. roxburghii and their functional properties. Recent studies showed the inhibitory effe...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
I recently attended the second Ending Age-Related Diseases conference in New York, hosted by the Life Extension Advocacy Foundation (LEAF). The mix of attendees was much the same as last year: an even split between scientists, entrepreneurs, investors, patient advocates, and interested onlookers, all focused on the treatment of aging as a medical condition. The presentations were similarly a mix of scientists talking about their research programs, entrepreneurs presenting on the data produced by their companies, and investors discussing the state of the industry. For my part, I have already presented several times t...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Darla Jaye, from The Woodlands, Texas, was diagnosed with breast cancer in February. She finished her final radiation treatment at Harris Health Systems on Monday, July 15.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Source: BMJ News - Category: General Medicine Source Type: research
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