The seasonal occurrence of Well’s syndrome
Abstract Well’s syndrome, in many circumstances, is determined by intensive eosinophilic infiltration into dermal layer with the clinical presentation of erythematous and edematous plaques which can easily be remitted by current corticosteroid therapies. Up to now, different etiologies have been proposed governing Well’s pathophysiological procedure. Of note, no evidence of seasonal association has been already reported. A 70-years-old afebrile male presented with a chief complaint of 30-years history of cutaneous manifestations along with non-ulcerated edematous, erythematous plaques and patches, and extensive pruritus confined on both dorsal and palmar surface of upper extremities occurred annually in early summer. We hereby report a case in season-dependent of Well’s syndrome occurrence.
We present a 48 year-old active duty physician who initially presented in 2007 with dyspnea and cough. Despite the absence of variable obstruction on spirometry, a clinical diagnosis of asthma was made. The patient's symptoms were temporized with inhaled corticosteroids and bronchodilators, titrated to his symptoms, until eventual therapeutic failure resulted in re-referral to pulmonary. Chest computed tomography (CT) showed ground-glass nodules and patchy airspace opacities with evidence of thoracic lymphadenopathy. A positron emission tomography CT (PET CT) showed diffuse adenopathy throughout his thorax and abdomen with...
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[CLINICAL PRACTICE GUIDELINES FOR THE MANAGEMENT OF ATOPIC DERMATITIS: SOME POINTS IN THE TREATMENT WITH TOPICAL CORTICOSTEROIDS]. Arerugi. 2019;68(9):1111-1114 Authors: Katoh N PMID: 31723106 [PubMed - in process]
ConclusionsAcute VZV infection may present as fulminant hepatitis. The presentation may initially be challenging for the diagnosis and should be considered if the patient has been in contact with a sick case. Low dose corticosteroid could carry a risk for fatal VZV fulminant hepatitis and should be used very cautiously especially with VZV patients’ contacts. Further causative relationships remain to be established.
Recent literature has advocated for the effectiveness of postoperative steroid injections following total knee arthroplasty (TKA) for improving pain and range of motion when other correctible causes of these symptoms have been eliminated. The safety of such injections has not been thoroughly evaluated. The aim of this study was to determine the risk of acute infection following intra-articular corticosteroid injection into a pre-existing TKA.
AbstractPurpose of this reviewTo highlight the evidence behind the various biologics that are being developed for asthma along with their specific targets in the inflammatory cascade and the potential role they serve in the management of allergic asthma.Recent findingsThe mainstay of asthma management for the majority of asthmatics is inhaled corticosteroids with or without long-acting beta-agonists and/or leukotriene modifiers and/or tiotropium. However, in the small group of individuals with severe asthma uncontrolled with conventional therapy, biologics have emerged as an effective therapeutic option.SummaryAsthma is a ...
Publication date: Available online 15 November 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Caroline M.B. Focke, Karl J. IremongerAbstractOscillations are a fundamental feature of neural and endocrine systems. The hypothalamic-pituitary-adrenal (HPA) axis dynamically controls corticosteroid secretion in basal conditions and in response to stress. Across the 24-h day, HPA axis activity oscillates with both an ultradian and circadian rhythm. These rhythms have been shown to be important for regulating metabolism, inflammation, mood, cognition and stress responsiveness. Here we will discuss the neural and endocr...
CONCLUSIONS: the prevalence of CeD in our patients with IBD was higher than that reported in the literature for other series of patients with IBD. A combination of anti-tTG testing and CeD genetics may screen patients for CeD in this population of patients with IBD. PMID: 31718200 [PubMed - as supplied by publisher]
ConclusionsThis study suggests the benefit of IVIg as adjunctive therapy, with an acceptable tolerance profile, and supports its use as a CS-sparing agent, in SScAM.