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Lyme disease-related intracranial hypertension in children: clinical and imaging findings

The objective of this study is to evaluate the history, clinical findings, CSF analysis, and brain imaging results in pediatric patients with increased intracranial pressure secondary to LD. A retrospective database search was performed using the International Classification of Diseases (ICD) 9/10 codes to identify patients diagnosed with LD and IH between 2004 and 2014 at a tertiary referral pediatric hospital. Clinical, laboratory and neuroimaging data for each patient were reviewed. Seven patients met inclusion criteria; mean age was 9.6 years (standard deviation 4.0 years); 4/7 patients were male. Average body mass index was 18.8 kg/m2 (standard deviation 3.0 kg/m2). Fever was present in four patients. Four had a history of LD related erythema migrans. All had elevated CSF opening pressure with leukocytosis and lymphocytic predominance. MRI obtained in six patients showed contrast enhancement of various cranial nerves. Tentorial enhancement was noted in all patients. In addition, patients had widening of the optic nerve sheath (ONS), optic nerve protrusion, and flattening of the posterior globe consistent with increased intracranial pressure. All patients had resolution of their symptoms after initiation of antibiotic therapy. In endemic areas, LD should be included in the differential of IH. MRI can help distinguish IH due to LD from its idiopathic form due to the presence of tentorial and cranial nerve enhancement in the former in addition to abnorma...
Source: Journal of Neurology - Category: Neurology Source Type: research

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Abstract Background: The prevalence of childhood obesity and associated conditions, such as hypertension, has become a major problem of public health. Although waist circumference (WC) is a marker of cardiovascular risk in adults, it is unclear whether this index is associated with cardiovascular risk factors in children. Objective: Our aim was to evaluate the association between increased WC and elevated blood pressure (BP) in children with normal body mass index (BMI) ranges. Methods: Cross-sectional evaluation of students between 6 and 11 years with normal BMI. WC was categorized by quartile for each age group. Normal B...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Polymerase chain reaction (PCR) is one of the most widely used techniques in biological research and testing, allowing researchers to amplify and identify even small quantities of DNA or RNA. It serves a wide variety of uses, from genetic testing to ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Diagnostics Genetics Source Type: blogs
Women who have had gestational diabetes have an increased risk not only for Type 2 diabetes later in life, but for heart disease and hypertension as well.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Diabetes Pregnancy and Childbirth Obesity Heart Weight Hypertension Source Type: news
Conclusions: It is imperative that patients on statin therapy be monitored carefully for NODM. However, it can be argued that the risk of statin therapy is offset by the multitude of cardiovascular and kidney-protective effects provided by such an important and highly effective therapeutic agent.Cardiorenal Med 2018;8:105 –112
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research
HIGH blood pressure symptoms are difficult to spot, but there are some signs that you could be at risk of the condition, which could lead to heart attacks and strokes.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Summary Seborrheic dermatitis is a common skin disorder occurring on the scalp, face and chest and is characterized by inflammation and a greasy scaling. It is not clear what causes seborrheic dermatitis, but it is thought that overgrowth of Malassezia yeasts contributes to developing seborrheic dermatitis. Several other factors have been associated with the disease as well; age, sex, obesity, skin colour, stress, depression, education level, hypertension, climate, xerosis cutis, alcohol and tobacco use have all been associated with seborrheic dermatitis, but the evidence for these associations was often not conclusive. Th...
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Plain Language Summary Source Type: research
ObjectivesTo investigate evidence for selected vector‐borne pathogen infections in dogs with pericardial effusion living in a Mediterranean area in which several canine vector‐borne diseases are endemic. Materials and MethodsArchived EDTA blood (n=68) and pericardial fluid samples (n=58) from dogs with pericardial effusion (n=68) were included. Dogs without pericardial effusion examined for other reasons were included as controls (n=60). Pericardial effusion was classified as neoplastic in 40 dogs, idiopathic in 23 dogs and of unknown aetiology in 5 dogs. Real‐time PCR was performed for Leishmania infantum, Ehrlichia...
Source: The Journal of Small Animal Practice - Category: Veterinary Research Authors: Tags: PAPER Source Type: research
Conclusions:Zika can induce GBS after a brief viral illness. Neuropathy can be a mixture of demyelinating and axonal. Dysautonomia may also be present including severe dysphagia, orthostatics and retention.Zika RNA has a short detection window in serum and CSF making a diagnosis time sensitive. Serological assays using IgM and IgG cross-react with other flaviviruses making them unable to differentiate between recent Zika exposure and cross reactivity with Dengue and Chikungunya. Our pt likely had prior exposure to Dengue, being from an endemic area. Prior Dengue exposure may possibly modulate the response to Zika via antib...
Source: Neurology - Category: Neurology Authors: Tags: Zika, Chikungunya, West Nile Virus, and Other Viral Infections I Source Type: research
Discussion Humans are opportunistic hosts to Babesia when bitten by nymph or adult ticks; the most known ticks are Ixodes. Babesiosis should be considered in patients who have a malaria-like illness in areas endemic for Babesia infection. The symptoms usually begin 2–4 weeks after a tick bite. The presentation includes constitutional symptoms, abdominal pain and dark urine. Labs finding include hemolytic anemia and elevated liver enzymes. Urinalysis reveals hemoglobinuria without red blood cells. The diagnosis of Babesiosis is usually established by microscopic examination of Giems or Wright-stained blood smears, ind...
Source: Journal of Investigative Medicine - Category: Research Authors: Tags: Infectious Disease Source Type: research
CONCLUSIONS: The reported incidence of LD in Poland, in our opinion, may be biased by overreporting and overdiagnosis. Nonspecific musculoskeletal and joint pain are the most frequent cause of LD suspicion and hospitalization. There is a necessity of better tests for active LD confirmation (especially in patients with musculoskeletal pain) as seroprevalence of anti Borrelia burgdorferi antibodies is high in endemic regions. PMID: 26641887 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - Category: Biomedical Science Authors: Tags: Adv Med Sci Source Type: research
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