Racial Variation in the Uptake of Oncotype DX Testing for Early-Stage Breast Cancer Breast Cancer

Conclusion We did not find racial disparities in ODX testing for node-negative patients for whom ODX testing is guideline recommended and widely covered by insurers. However, our findings suggest that a newer, non–guideline-concordant application of ODX testing for node-positive breast cancer was accessed less by black women than by non-black women, reflecting more guideline concordant care among black women.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Chemotherapy, Quality of Care Breast Cancer Source Type: research

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MONDAY, Nov. 18, 2019 -- Using herbal products to treat breast cancer that's spread to the skin could slow wound healing and interfere with chemotherapy or hormone treatment, an expert warns. Many patients try herbal products and creams to treat...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
ConclusionIt is important to maintain a suspicion for GI tract metastasis in breast cancer patients who present with abdominal mass or GI symptoms, as this aids in prompt institution of accurate and appropriate management.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
AbstractBackgroundPredictive online calculators are used by clinicians as decision aids in early breast cancer (EBC). While use statistics for these calculators have not been published, as of 2017 NHS Predict was being accessed more than 20,000 times a month. These predictive tools have not had accuracy&benefit of use prospectively confirmed in EBC, yet use of calculators has been encouraged in EBC guidelines. It is important to understand the populations informing model development&validation, to understand how data bias may impact predictions in under-represented subpopulations. This work sought to elucidate the ...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Improvement of supportive care quality for women with breast cancer who are undergoing chemotherapy in Thai culture should include: 1) access to supportive care needs assessment, 2) proactive dissemination of necessary information for better management of their lives, 3) aids to daily living and psychosocial support, and 4) facilitation of easy access to welfare and finance help. Provision of supportive care from both families and health care teams could improve the quality of life and so ease the women's lives for Thai women with breast cancer undergoing chemotherapy. PMID: 31358262 [PubMed - in process]
Source: European Journal of Oncology Nursing - Category: Nursing Authors: Tags: Eur J Oncol Nurs Source Type: research
Purpose: Viral hepatitis can cause significant morbidity and mortality in patients receiving chemotherapy. London cancer guidelines recommend universal pretreatment screening for hepatitis B (HBV) and hepatitis C (HCV). HIV-infected patients are at higher risk of developing AIDS-defining and non-AIDS-defining cancers. HIV testing for all oncology patients has been recommended. Studies reveal up to 30% of breast cancer patients may have undiagnosed diabetes [1]. Oncology patients with diabetes have an increased risk of complications: chemotherapy toxicities, steroid-induced hyperglycaemia and sepsis.
Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionWe developed a predictive model using machine learning that could represent a useful and easy-to-access tool for the selection of high ODX RS patients. After additional evaluation with large data and external validation, worldwide use of our model could be expected.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Authors: Schwartzberg LS Abstract All patients with early breast cancer should be classified by subgroup through testing estrogen receptor, progesterone receptor, and HER2 status, with or without Ki-67 proliferation percentage. Genomic expression profiling aids clinical decision-making in most patients, because most are estrogen receptor-positive. The commercially available classifiers are prognostic for distant recurrence in node-negative and also node-positive patients. Patients at genomically low risk have excellent 5-year outcomes with endocrine therapy alone. Some assays also predict for benefit from adjuvant ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
ConclusionsWe need to encourage SDM in breast reconstruction. We need information systems available to patients prior to breast reconstruction like educational meetings, giving healthcare professionals feedback, giving healthcare professionals learning materials, and using patient decision aids.Shared decisions leads to better outcomes and high patient's satisfaction in breast reconstruction.Citation Format: Choi YJ, Lee JH, Moon SY, Choi JY, Jung SP, Bae JW, Park KH. Changes of tumor-infiltrating lymphocytes and programmed death-ligand1 positivity after neoadjuvant chemotherapy in patients with locally advanced breast can...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
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