CNS Metastases in Patients With Non-Small-Cell Lung Cancer and ALK Gene Rearrangement EDITORIALS

Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Brain Tumors, Combined Modality EDITORIALS Source Type: research

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CONCLUSIONS: For brain cancer patients, HCMV-reactivation after the start of radiochemotherapy is a frequent risk for cognitively detrimental but treatable encephalopathy and premature death. Routinely performed HCMV-diagnostics, assessing basophil counts and study-based anti-viral regimens are necessary to combat this hidden threat. PMID: 32060103 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
ConclusionSequencing of CSF ctDNA revealed specific mutation patterns in driver genes among patients with NSCLC and brain metastasis.Key pointsIn some small ‐sample studies, the importance of cerebrospinal fluid in guiding the treatment of cancerous brain lesions has been verified in that it may reflect genomic mutations of brain tumors relatively accurately.Cerebrospinal fluid is a new form of liquid biopsy that can be helpful in improving the management of patients with brain metastasis from non ‐small cell lung cancer by detecting genetic abnormalities specific to brain metastases.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: Both WBRT and SRS are appropriate for the treatment of BM in patients with ALK-rearranged NSCLC. The incidence of BM in the hippocampus and peri-hippocampus region is low in our radiological data. Nearly 80% of patients with metachronous BM have oligo-metastatic lesions, indicating that SRS is the preferred therapy while PCI is not indicated.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Rationale: One-and-a-half syndrome (OAAH) is characterized as the combination of ipsilateral horizontal gaze palsy and internuclear ophthalmoplegia. OAAH syndrome accompanied with 7th and 8th cranial nerve palsy is called 16-and-a-half syndrome. We aimed to report the case of 16-and-a-half syndrome with metastatic pons tumor. Patient concerns: A 57-year-old male diagnosed with nonsmall-cell lung cancer (NSCLC) with brain metastasis occurring 15 months ago was referred to our clinic with the chief complaint of horizontal diplopia and right gaze palsy. Diagnosis: According to the patient symptom, ocular examination, ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In this study, we aimed to explore the efficacy and safety profile of apatinib monotherapy, or combined with chemotherapy or endothelial growth factor receptor (EGFR)-TKI in heavily pretreated non-small cell lung cancer (NSCLC) patients with brain metastases. We performed a retrospective analysis for relapsed NSCLC patients with brain metastases from our institute, whom received apatinib (250mg or 500mg p.o. qd) monotherapy, or combination with EGFR-TKI or chemotherapy as second- or more line systemic therapy until disease progression or unacceptable toxicity occurred. The objective response rate (ORR), disease control rat...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
ConclusionsThe frequency of PD-L1+ myeloid cells correlated with the presence of brain metastases.  Tumor-derived IL-6 was capable of inducing PD-L1+ myeloid cells  in vitro, suggesting that monitoring of immunosuppressive factors in peripheral blood may identify new targets for therapeutic intervention in selected patients.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
(Stand Up To Cancer) SU2C supported researchers will present work on pediatric brain tumors, cfDNA for early cancer detection, dual blockade of CTLA-4 and PD-1 in mCRC, cancer interception of pancreatic and lung cancers, machine learning RECIST in RWE study of lung cancer, and molecular markers of response to neoadjuvant nivolumab in resectable NSCLC.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Authors: Kaley T, Nabors LB Abstract Meningiomas represent a full spectrum of tumors that are the most common type of brain tumor in adults. Although most are benign, recent research has shown that the recurrence rate is high, especially for WHO grades 2 and 3, and overall survival is poor for these grades. Treatment is evolving, and recently sunitinib and bevacizumab have shown promise compared with historical treatments. However, more research is needed to identify better treatments for meningiomas. Treatment of brain metastases is another evolving field. Studies suggest that stereotactic radiosurgery is preferab...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
In this study, five non-small cell lung cancer cell lines with different levels of EGFR were used to investigate their ability to recognize EGFR expression through in vitro, ex vivo and in vivo experiments with [68Ga]Ga-NOTA-Affibody probes, and then to evaluate the value of positron emission tomography (PET) imaging in vivo diagnosis of EGFR-positive tumors. Methods: Purified Affibody analogues (Ac-Cys-ZEGFR:1907, bond to EGFR), synthesized by solid phase, and 1,4,7-three nitrogen heterocyclic nonane-1,4-7-three acetic acid (NOTA) produced conjugated compounds NOTA-ZEGFR:1907, which was labeled by [68Ga]Ga at 80℃ for 15...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology, Basic and Translational (Basic Science) Posters Source Type: research
AbstractPurposeMetastatic non-small cell lung (NSCLC) cancer represents one of the most common types of brain metastasis. The mechanisms involved in how circulating cancer cells transmigrate into brain parenchyma are not fully understood. The aim of this work was to investigate the role of fucosylated carbohydrate epitopes CD15 and sialyated CD15s in cancer adhesion to brain-derived endothelial cells and determine their influence in blood –brain barrier (BBB) disruptionMethodsThree distinct, independent methods were used to measure brain endothelial integrity and include voltohmmeter (EVOM ™), impedance spectro...
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
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