ELF5 isoform expression is tissue-specific and significantly altered in cancer

Conclusions: Alternative promoter use, conferring differential regulatory responses, is the main mechanism governing ELF5 action rather than differential transcriptional activity of the isoforms. This understanding of expression and function at the isoform level is a vital first step in realizing the potential of transcription factors such as ELF5 as prognostic markers or therapeutic targets in cancer.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research