Well: Think Like a Doctor: Thunder in the Head
Can you solve a real-life medical mystery involving a 59-year-old man tormented by a thunderous pounding in his head?
Interview with Christopher R. Cederroth, PhD, author of Association of Genetic vs Environmental Factors in Swedish Adoptees With Clinically Significant Tinnitus
This study uses Swedish national registry data to assess the association between genetic vs environmental factors and risk of tinnitus among adoptees.
Genetic factors are fundamental in the molecular pathologic mechanisms of a number of auditory disorders that present throughout the lifespan. Historically, an understanding of the role of genetics in tinnitus has not been as straightforward because it can be viewed as a symptom of multiple diseases. Risk factors for tinnitus include hearing loss, aging, and noise exposure, most logically connecting its cause with environmental factors. This notion has been supported by a lack of heritability determined from early family-based questionnaire studies. In addition, previous studies that have primarily used genotyping in the p...
Condition: Tinnitus Intervention: Other: Physical Therapy Sponsor: VA Office of Research and Development Not yet recruiting
Conclusion: Round window niche drilling increases the contact area and time of methylprednisolone. It is an effective and safe salvage therapy of idiopathic SSNHL and its induced tinnitus.Audiol Neurotol 2018;23:309 –315
Purpose of review Recent enthusiasm for cannabinoid drugs for the treatment of chronic pain and some forms of epilepsy, raises the question of whether they could be useful for other disorders associated with abnormal neuronal activity in the brain, such as subjective tinnitus. Indeed, there is evidence to indicate that some tinnitus sufferers self-medicate using Cannabis. The aim of this review is to critically evaluate the available evidence relating to the effects of cannabinoids on tinnitus. Recent findings Despite the fact that cannabinoids have been shown to decrease neuronal hyperactivity in many parts of the br...
We report the case of a 42-year-old patient referred for suspicion of fibromuscular dysplasia in the context of a carotid artery dissection occurring after a minor trauma. Initial complaints included left hemicrania, lateral diplopia with left 6th cranial nerve palsy and pulsatile tinnitus. The work-up disclosed a large left carotid-cavernous fistula, as well as more proximal carotid lesions compatible with multifocal fibromuscular dysplasia. Personal history included colonic and uterine perforation. Family history disclosed a fatal hemorrhage due to rupture of a splenic artery aneurysm in the father and an iliac dissectio...
Discussion: Our review has not identified any reliable or reproducible objective measures of tinnitus. However, this piece of work has highlighted emerging areas where further high quality research may lead to the development of an effective method for objectively identifying and measuring the severity of tinnitus.
Conclusions: Transtympanic resurfacing with bone cement, reinforcing the dehiscent JB to reduce focal turbulent flow, is a simple and effective surgical treatment option in patients with PT due to HJBD. In patients with HJBD, the objective measurement of PT by TSR/STA may be of help in selecting appropriate surgical candidates and objective evaluation of the treatment outcome.
Conclusions: Daily portable audiometry is feasible in patients with MD. Future studies are planned to further analyze hearing fluctuations in MD with respect to frequencies affected, relationship to vertigo attacks, and response to treatments. Understanding hearing fluctuations in MD may aid refinement of diagnostic criteria and improve prognostication for long-term hearing loss, with a goal of informing treatments that might improve final hearing outcome.