Systemic immune activity predicts overall survival in treatment naïve patients with metastatic pancreatic cancer.

Systemic immune activity predicts overall survival in treatment naïve patients with metastatic pancreatic cancer. Clin Cancer Res. 2015 Dec 30; Authors: Farren MR, Mace T, Geyer S, Mikhail S, Wu C, Ciombor KK, Tahiri S, Ahn D, Noonan AM, Villalona-Calero MA, Bekaii-Saab T, Lesinski GB Abstract BACKGROUND &AIMS: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research

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Immune checkpoint inhibitors can be effective in patients with non-small cell lung cancer and mild interstitial lung disease, but with a greater risk.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Pulmonary Medicine News Source Type: news
AbstractPurposeGenetic variants may influence the pharmacokinetics and pharmacodynamics (PKPD) of cyclophosphamide (CY). CY plays a critical role in conditioning chemotherapy for hematopoietic cell transplantation (HCT), but its use is limited by toxicity. We explored the effect of genetic variants, potentially affecting PKPD of CY, and outcomes after HCT.MethodsThis observational pharmacogenomic study included 85 adults with hematologic malignancies who received reduced intensity conditioning with CY, fludarabine, and total body irradiation. We collected recipient DNA prior to HCT and evaluated 97 candidate variants in 66...
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Oncogene, Published online: 27 January 2022; doi:10.1038/s41388-021-02158-wSELENOF is a new tumor suppressor in breast cancer
Source: Oncogene - Category: Cancer & Oncology Authors: Source Type: research
Oncogene, Published online: 27 January 2022; doi:10.1038/s41388-021-02159-9A low amino acid environment promotes cell macropinocytosis through the YY1-FGD6 axis in Ras-mutant pancreatic ductal adenocarcinoma
Source: Oncogene - Category: Cancer & Oncology Authors: Source Type: research
Dalton Trans., 2022, Accepted Manuscript DOI: 10.1039/D1DT04315C, PaperXiang Wang, Kang Song, Yong Deng, Jie Liu, Qin Peng, Xiao Lao, Jiayu Xu, Dong Wang, Turong Shi, Yuhao Li, Dan Deng, Yuqing Miao Photodynamic therapy (PDT) is an effective non-invasive treatment for tumors. The structure of the photosensitizer has an important influence on the light utilization and the efficiency of singlet-oxygen generation. In... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2022, Advance Article DOI: 10.1039/D1CC06330H, CommunicationXiao-Jie Dong, Wen-Yan Li, Qun Guan, Yan-An Li, Yu-Bin Dong A COF-based multifunctional nanomedicine CuS@COF-BDP, which can be used as a PTT/PDT bimodal therapeutic agent to inhibit cancer cell proliferation under visible- and NIR-II-light irradiation, is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
ConclusionsDecompression using a SEMS as the BTS may improve oncological outcomes over those achieved by a TDT in patients with left-sided stage II and III OCRC.
Source: Surgery Today - Category: Surgery Source Type: research
AbstractPurposePrevious studies have reported that sarcopenia increases the risk of postoperative complications following colorectal resection. This retrospective study assessed the postoperative complications of rectal resection associated with sarcopenia.MethodsWe retrospectively analyzed 262 patients who underwent curative low anterior resection for primary rectal cancer from January 2008 to May 2020 at our institution. The patients were divided into a sarcopenia group (normalized total psoas muscle area  
Source: Surgery Today - Category: Surgery Source Type: research
Conclusions: RS predicted worse LRR and OS in R-PDAC and worse LRR, DR, and OS in BR/LA-PDAC. This may select patients who would benefit from radiation and should be validated prospectively.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with poor survival rates. For borderline resectable or unresectable disease, intensive multi ‐drug chemotherapy regimens with either modified FOLFIRINOX (mFOLF) or nab‐paclitaxel plus gemcitabine are preferred. We retrospectively compared these two chemotherapy regimens in patients who completed resection and found the mFOLF group had better overall clinical and pathological response ra tes. Randomized clinical trials are needed, and this study provides valuable information in the interim. AbstractWe conducted an institutional study to compare the clinical and...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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