Could a cholesterol-lowering drug be a potential treatment for Parkinson's?

A clinical trial using cholesterol-lowering treatment Simvastatin in people living with Parkinson's is getting underway in centers across England -- with the hope that it could become one of a number of effective treatments available to treat Parkinson's.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Conclusion: Our results provide strong evidence that ERK1/2-mediated modulation of the anti-oxidant system after simvastatin treatment may partially explain the anti-oxidant activity in experimental parkinsonian models. These findings contribute to a better understanding of the critical roles of simvastatin via the ERK1/2-mediated modulation of the anti-oxidant system, which may be relevant for treating PD.Cell Physiol Biochem 2018;51:1957 –1968
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
This article, however, is more of a commentary on high level strategy and the effects of regulation, coupled with a desire to forge ahead rather than hold back in the matter of treating aging, thus I concur with much more of what is said than is usually the case. For decades, one of the most debated questions in gerontology was whether aging is a disease or the norm. At present, excellent reasoning suggests aging should be defined as a disease - indeed, aging has been referred to as "normal disease." Aging is the sum of all age-related diseases and this sum is the best biomarker of aging. Aging and its d...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
I have posted a few notes about predictive diagnostic algorithms (see:An Algorithm Using Medical Record Data Predicts Risk for Parkinson's Disease;Should the Work Product of"Non-Explainable" Medical Algorithms Be Ignored) and disease risk scores (see:Genetic Risk Scores: Ready for Inclusion in the Medical Record?). Using AI techniques, researchers at Massachusetts General are developing a web site that will display a risk score for five common diseases after consumers upload their DNA to the site (see:Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA). The algorithm takes into account mill...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Clinical Lab Industry News Clinical Lab Testing Genomic Testing Healthcare Information Technology Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Medical Research Source Type: blogs
Movement Disorders, EarlyView.
Source: Movement Disorders - Category: Neurology Authors: Source Type: research
(Natural News) What if the drug meant to treat you actually gave you a different, just-as-bad disease? A report published in the medical journal Movement Disorders says this could be the case with statins, linking the use of the drugs to an increased risk of Parkinson’s disease. Statins are a class of drugs prescribed to...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
DISCUSSION: Overall, the literature supports beneficial pleotropic effects of statin use in contrast-induced nephropathy, head injury, Alzheimer's and Parkinson's disease, nuclear cataract, prostate cancer, infection management, and spinal cord injury. Further investigation is warranted, and randomized clinical trials are needed to confirm the clinical utility suggested by the reported studies included in this meta-analysis. PMID: 30033872 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
In conclusion, the connection between DNA damage and aging is emphasized by the secretion of senescence-associated proteins during cellular senescence, a phenotype which is activated by DNA damage and is common for both human and mice. Though much progress has been achieved, full understanding of these mechanisms has still a long way to go. XPO1 as a Novel Target for Therapies to Enhance Autophagy https://www.fightaging.org/archives/2018/05/xpo1-as-a-novel-target-for-therapies-to-enhance-autophagy/ Autophagy is the name given to a collection of cellular housekeeping processes that recycle damaged and un...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The objective here is a set of tests that (a) match up to the expected outcome based on human trials of mitochondrially targeted antioxidants, and (b) that anyone can run without the need to involve a physician, as that always adds significant time and expense. These tests are focused on the cardiovascular system, particularly measures influenced by vascular stiffness, and some consideration given to parameters relevant to oxidative stress and the development of atherosclerosis. A standard blood test, with inflammatory markers. An oxidized LDL cholesterol assessment. Resting heart rate and blood pressure. Heart r...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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