Model-free Estimation of Recent Genetic Relatedness

Genealogical inference from genetic data is essential for a variety of applications in human genetics. In genome-wide and sequencing association studies, for example, accurate inference on both recent genetic relatedness, such as family structure, and more distant genetic relatedness, such as population structure, is necessary for protection against spurious associations. Distinguishing familial relatedness from population structure with genotype data, however, is difficult because both manifest as genetic similarity through the sharing of alleles.

Source: The American Journal of Human Genetics - January 7, 2016 Category: Genetics & Stem Cells Authors: Matthew P. Conomos, Alexander P. Reiner, Bruce S. Weir, Timothy A. Thornton Tags: Article Source Type: research