This Month in Genetics

As the term polyQ disorder implies, Huntington disease (HD) is thought to be due almost exclusively to the toxicity of the expanded polyglutamine-containing tract in the open-reading frame of the gene. For some other trinucleotide repeat disorders caused by repeat expansions outside of the open-reading frame, repeat-associated non-ATG (RAN) translation has been implicated in disease pathogenesis, leading Laura Ranum and colleagues to explore whether this atypical form of protein translation has a role in HD.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Editors ’ Corner Source Type: research