An Efficient Multiple-Testing Adjustment for eQTL Studies that Accounts for Linkage Disequilibrium between Variants

We present an alternative correction method called eigenMT, which runs over 500 times faster than permutations and has adjusted p values that closely approximate empirical ones.

Source: The American Journal of Human Genetics - December 31, 2015 Category: Genetics & Stem Cells Authors: Joe R. Davis, Laure Fresard, David A. Knowles, Mauro Pala, Carlos D. Bustamante, Alexis Battle, Stephen B. Montgomery Tags: Report Source Type: research