UCLA scientists test new strategy that could help fight ovarian cancer

UCLA scientists have developed a promising novel method to treat gynecologic tumors. The approach focuses on a protein called p53, which is commonly mutated in women who have high-grade serous ovarian cancer, the deadliest form of reproductive cancer. In many women with the disease, the cancer is very advanced by the time it is diagnosed and is therefore difficult to treat. The discovery was the result of a three-year study co-led by David Eisenberg and Dr. Sanaz Memarzadeh, members of the UCLA Jonsson Comprehensive Cancer Center. The findings, which were published online in the journal Cancer Cell, could ultimately lead to new targeted therapies for many other types of cancer carrying similar p53 mutations. P53 is known as the “guardian of the genome.” It prevents damaged cells from reproducing by stopping their growth until the damage is repaired or, if the damage cannot be reversed, promotes cell death. But mutations, which are found in 96 percent of patients with high-grade serous ovarian tumors, can cause p53 to form clumps, or “aggregates,” which impair the protein’s normal function. As a result, the damaged cells are able to multiply uncontrollably, which can lead to cancer. The UCLA scientists developed and tested a peptide called ReACp53, which penetrates cancer cells and prevents mutated p53 from clumping together. The technique restores normal p53 function, causing death of the ovarian cancer cells. “Our lab has worked for 15 yea...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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In this study, we propose a new Gaussian graphical model-based method to infer differential networks by integrating gene expression and static gene regulatory network data. We first evaluate the empirical performance of our method by comparing with the state-of-the-art methods using simulation data. We also apply our method to The Cancer Genome Atlas data to identify gene network rewiring between ovarian cancers with different platinum responses, and rewiring between breast cancers of luminal A subtype and basal-like subtype. Hub genes in the estimated differential networks rediscover known genes associated with platinum r...
Source: IEEE/ACM Transactions on Computational Biology and Bioinformatics - Category: Bioinformatics Source Type: research
ConclusionsA considerable number of gynaecologists would perform a staging procedure that is recommended for ovarian cancer in case of an ambiguous BOT frozen section diagnosis, especially for serous tumours. In addition, nearly all gynaecologists would perform a second procedure including a lymph node sampling in case of a serous invasive carcinoma after a BOT frozen section diagnosis, which applies to half of the gynaecologists in case of a mucinous carcinoma.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Instead of mind-boggling inventions, 2018 was the year when national governments, as well as healthcare regulators, started to embrace digital health technologies at scale. The year when Google, Amazon, Apple or Microsoft competed head-to-head for the biggest chunks on the healthcare market, and when the buzzword of the year award went to the blockchain. Here’s our guide to the top digital health stories from last year. 2018: Under the spell of cosmos and microcosmos Every year, The Medical Futurist team sits down and collects the top stories of the past 12 months in healthcare. We put the novelties under the microsc...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Business Future of Medicine Medical Professionals Patients Policy Makers Researchers Top Lists 2018 AI artificial intelligence artificial pancreas blockchain chatbot CRISPR deep learning diabetes digital health digital he Source Type: blogs
This article is to summarize clinical and pathological features, diagnosis and differential diagnosis, treatment, and prognosis of UTROSCT.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
BOSTON (CBS) – Alex Fitzpatrick went from Hollywood screenwriter to Massachusetts restaurant owner so she and her husband could spend more time with her children. When she recently found out her risk of getting breast cancer was as high as 80%, all she could think of was her three boys. “I do want to make sure that I’m the one telling them what to wear on their wedding day and watch them go to college,” she said. Alex has one of the BRCA gene mutations. She got tested when an aunt was recently diagnosed with an aggressive form of breast cancer. “I was blindsided to be honest,” she remem...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Watch Listen Angelina Jolie Breast Cancer Dr. Mallika Marshall Mass General Hospital Source Type: news
Publication date: Available online 10 December 2018Source: Journal of Molecular StructureAuthor(s): N.A. Sanina, G.I. Kozub, O.S. Zhukova, D.V. Korchagin, T.A. Kondrat'eva, R.B. Morgunov, A.D. Talantsev, N.S. Ovanesyan, A.V. Kulikov, S.M. AldoshinAbstractNew method for the synthesis of the mononuclear anionic iron dinitrosyl complexes (DNICs) as prospective agents for nitric oxide (NO) chemotherapy of oncological diseases has been developed. Mononuclear anionic DNIC of the composition (N2H5)+[Fe(SR)2(NO)2]- with R = 5-nitropyridinyl (I) has been synthesized by the reaction of aqueous solutions of Na2[Fе(S2O3)2(NO)2] a...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
ConclusionsResection of diaphragm metastases by MIS appears to be feasible and safe for selected patients, with similar recurrence as other abdominal sites.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
CONCLUSIONS LINC01118 acted as an oncogene and modulated EOC paclitaxel sensitivity by regulating miR-134/ABCC1. PMID: 30521500 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conclusion: The increases in the incidence of different types of cancer in the past decade could be due to the revolutionary change in socioeconomic status that has occurred in Saudi Arabia; therefore, a national plan should be established for cancer prevention, screening and therapy. Concerning mortality, the decrease in its percentage among elderly people could be due to biological factors that should be investigated in the future. PMID: 30520511 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Conclusion Goal measurement is feasible in cancer rehabilitation, in both goal setting and goal achievement. Goal achievement less than expected levels in women recovering from ovarian or cervical cancer suggests a need for additional support. Implications for Practice This study supports goal setting and goal achievement as a feasible approach to improve cancer rehabilitation and that nursing professionals can facilitate individualized rehabilitation efforts.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
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