Cancer immune contexture and immunotherapy.

Cancer immune contexture and immunotherapy.
Curr Opin Immunol. 2015 Dec 17;39:7-13
Authors: Becht E, Giraldo NA, Dieu-Nosjean MC, Sautès-Fridman C, Fridman WH
Abstract
The immune contexture that characterizes the density, the location, the organization and the functional orientation of tumor-infiltrating immune cells in cancers has a clinical impact on patient's outcome. It is, in great part, shaped by the malignant cells, as in a given cancer type, tumors presenting different oncogenic processes have different immune contextures. Moreover, the immune contexture in metastatic sites reflects that of the corresponding primary tumors. Finally, the components forming the immune contexture represent targets and markers of efficient anti-cancer immunotherapies.
PMID: 26708937 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - December 17, 2015 Category: Allergy & Immunology Authors: Becht E, Giraldo NA, Dieu-Nosjean MC, Sautès-Fridman C, Fridman WH Tags: Curr Opin Immunol Source Type: research