Mapping a way to medication adherence

Eighteen-year-old Maggie Mansfield, a communications major at Boston College, is a two-time double-lung transplant recipient — once, at age 4, due to a condition called pulmonary hypertension in which blood pressure in the arteries of the lungs is abnormally high, and again at age 7, when her body rejected the first transplant. Since then, Maggie has remained relatively healthy due in part to her strict medication regimen. Maggie Mansfield “Timing is the most challenging part of taking my medications,” Maggie says. “As I get older, I get busier. It’s not always easy to stop what I am doing and take my pills, but I try to keep my timing the same so I don’t throw off my labs.” Medication adherence is critical to the long-term health of an organ recipient. But taking upwards of 20 medications per day is often overwhelming, particularly for adolescents and young adults as they become more independent. “I equate it to learning how to drive a car,” says Kristine McKenna, PhD, a psychologist in the Boston Children’s Hospital Pediatric Transplant Center. “We don’t just toss over the keys. There are a lot of steps to learning — getting a learner’s permit, practicing driving with a parent. And, again, we don’t just send them out to drive across the country when they get their license.” Drivers Ed: Learning the basics Maggie began taking responsibility for her medications when she was 12...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Health & Wellness Our Patients’ Stories Teen Health double lung transplant Liver transplant Pediatric Transplant Center (PTC) prescription medication pulmonary hypertension Source Type: news

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Lobar lung transplantation is known as an alternative for higher Donor/Receiver mismatch in cystic fibrosis or idiopathic pulmonary fibrosis patients. Using lobar lung transplantation for Pulmonary Hypertension remains questionable because of the higher risk of primary graft dysfunction. We thought to determine wether lobar lung transplantation from brain-dead donors is an option for Pulmonary Hypertension.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
AbstractBackground and objective:Pulmonary hypertension (PH) is frequently found in advanced parenchymal lung diseases like cystic fibrosis (CF), but the role played by PH in the clinical outcome of CF patients remains unclear. The aim of this study is to determine the influence of PH on survival in the CF population by meta-analysis.Methods:Publications addressing the associations between PH and overall survival (OS) or other clinical characteristics in CF patients were selected from electronic databases. Odds ratios (ORs) or mean differences (MDs) were used to estimate the association between PH and the clinical characte...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
 >>>Available Here with Free Look Inside Option Correct answer: 3. Both 1 and 2 In domino heart transplantation, the donor receives heart lung transplantation. The excised heart is transplanted to another recipient so that the donor for recipient of domino heart transplantation is alive, unlike the conventional donor who is brain dead. In one report of 10 cases of domino heart transplantation, one year survival of donor was 60% while that of recipient was 90% [1]. It worthwhile noting that donors had terminal cardio pneumopathy (mostly primary pulmonary hypertension, one case of Eisenmenger syndrome and ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Background:Studies concerning phenotypes in bronchiectasis are limited and describtion of phenotypes of non-cystic fibrosis (non-CF) bronchiectasis might be helpful for correct management of this disease.Objective:The aim of this study was to describe the clinical functional and microbiological phenotypes of patients with non-CF bronchiectasis.Methods:A monocentric retrospective study in a pulmonary medicine department of Medical University Hospital in Azerbaijan republic was conduted over 5 years (2010-2015).Non-CF bronchiectasis patients with tomographic confirmation were included.Results:Of the 183 included patients, an...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
Conclusion: We strongly recommend the long term cardiovascular follow up on lung transplanted patient, because of the common systemic atherogen effect of the frequent infection and immunsupressive therapy.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
Cystic fibrosis and non-cystic fibrosis bronchiectasis share as their main clinical hallmark repeated lung infections by opportunist pathogens. In the normal adult lung, almost no lymphoid tissue is observed, in contrast to fetal and paediatric lungs [1] and in contrast to upper airways [2]. Neogenesis of bronchial-associated lymphoid tissue (BALT), also referred to as induced BALT (iBALT) or ectopic lymphoid follicles, has been observed in several chronic lung diseases, including chronic obstructive pulmonary disease (COPD) [3], lung cancer [4], pulmonary hypertension [5], post-transplant restrictive allograft syndrome [6...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: CF and non-CF bronchiectasis Editorials Source Type: research
Abstract S-nitrosoglutathione reductase (GSNOR) is a multifunctional enzyme. It can catalyze NADH-dependent reduction of S-nitrosoglutathione (GSNO); as well as NAD(+)-dependent oxidation of hydroxymethylglutathione (HMGSH; an adduct formed by the spontaneous reaction between formaldehyde and glutathione). While initially recognized as the enzyme that is involved in formaldehyde detoxification, increasing amount of research evidence has shown that GSNOR also plays a significant role in nitric oxide mediated signaling through its modulation of protein S-nitrosothiol abundance via transnitrosation reactions with GSN...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research
Abstract Nonessential amino acids are synthesized de novo and therefore not diet dependent. In contrast, essential amino acids must be obtained through nutrition since they cannot be synthesized internally. Several nonessential amino acids may become essential under conditions of stress and catabolic states when the capacity of endogenous amino acid synthesis is exceeded. Arginine and glutamine are 2 such conditionally essential amino acids and are the focus of this review. Low arginine bioavailability plays a pivotal role in the pathogenesis of a growing number of varied diseases, including sickle cell disease, t...
Source: Nutrition in Clinical Practice - Category: Nutrition Authors: Tags: Nutr Clin Pract Source Type: research
February 2017 UpdateThe February 2017 revision of the Cochrane Priority Reviews List includes new titles from the Cochrane Acute Respiratory Infections, Cystic Fibrosis&Genetic Disorders, ENT, Musculoskeletal, and Wounds Groups.The following titles on the list are open to new authors:Biomarkers for predicting outcomes in endometrial cancer (Gynaecological, Neuro-oncology and Orphan Cancer)Diagnostic test accuracy of sentinel LN node sampling in endometrial cancer (Gynaecological, Neuro-oncology and Orphan Cancer)Immunomodulatory treatment for amyotrophic lateral sclerosis /motor neuron disease (ALS/MND) (Neuromuscular ...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
This article summarizes current clinical standards in pulmonary imaging and introduces the reader to new innovative techniques of functional lung imaging. In the context of actual clinical studies for COPD, asthma, pulmonary hypertension and cystic fibrosis the application of quantitative imaging methods using computed tomography and magnetic resonance imaging is demonstrated and possible future applications are discussed. PMID: 27931057 [PubMed - in process]
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
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