Cancer and infertility medication 'show promise as new antibiotics'

University of Illinois at Urbana-Champaign scientists found current drugs can work as antibiotic agents against staph and tuberculosis infections - and are harder for bacteria to resist.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Many agencies that offer donated embryos, including most of those supported by federal grants, are affiliated with Christian or anti-abortion rights organizations.
Source: NYT Health - Category: Consumer Health News Authors: Tags: In Vitro Fertilization Infertility Adoptions Health and Human Services Department embryos Abortion Faith-Based Initiatives Source Type: news
Publication date: February 2019Source: Best Practice &Research Clinical Obstetrics &Gynaecology, Volume 55Author(s):
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
ConclusionsWe found the precise anatomy of the connective tissue layer from umbilical artery to urinary bladder and the superior vesical artery. Our procedure based on the precise anatomy obtained in this study is reasonable anatomically as a method for separation of the vesicouterine ligament during radical hysterectomy.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
This study investigated the modulation of micro-RNAs associated with the PI3K/AKT/mTOR-axis by mango polyphenols (MP) in MCF-12A non-cancer and MDA-MB231 breast cancer cell lines. MP reduced proliferation in the cancer cells by up to 90% (10 mg GAE/L) but did not cause cytotoxicity in the non-cancer cells within the same concentration range. In contrast, in TNF-α-treated non-cancer MCF-12A cells, MP significantly decreased expression and phosphorylation of NF-κB while modulating mRNA and protein levels of PI3K/AKT/mTOR and up-regulated miR-126. The mechanistic involvement of miR-126 was investigated using its...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
In this study, Se-enriched peanut protein nanoparticles-stabilized Pickering emulsions (PPEs) were used to encapsulate 5DN to enhance its bioaccessibility, cellular uptake and transport rate. The preparation of PPEs, and their digestion profiles in gastrointestinal tract, cell uptake and transport were investigated. Results showed that the bioaccessibility of 5DN was significantly higher within PPEs (18.3%) than in bulk oil (9.2%). Besides, PPEs-encapsulated 5DN has a greater apical-to-basolateral (AP-BL) transport rate (26.9 × 10−6 cm s−1) than 5DN (21.7 × 10−6 cm s−1). ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: April 2019Source: Journal of Functional Foods, Volume 55Author(s): Chia-Yuan Chang, Bing-Ying Ho, Tzu-Ming PanAbstractColorectal cancer (CRC) is a major cause of cancer-related deaths worldwide. Chemotherapy is the usual treatment, but entails side effects. Although lactic acid bacteria (LAB) ameliorate CRC, the effects of LAB-fermented skim milk are unknown. Thus, we investigated the effect of Lactobacillus paracasei subsp. paracasei NTU 101-fermented skim milk (NTU 101FM) in combination with chemotherapy on CRC, and its effect on chemotherapeutic side effects in vivo. NTU 101FM + chemotherapy treatm...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Human β-defensin 1 update: potential clinical applications of the restless warrior. Int J Biochem Cell Biol. 2018 Sep 17;: Authors: Álvarez ÁH, Velázquez MM, de Oca EPM Abstract Human β-defensin 1 (hBD-1) is a multifaceted antimicrobial peptide being a tumour suppressor and, depending on call of duty, capable of inducing self-nets and neutrophil extracellular traps (NETs) to trap and/or kill bacteria, participates in inflammatory responses in chronic diseases including hBD-3 upregulation and also capable of up/downregulation in the presence of certain species of Lactobac...
Source: The International Journal of Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Int J Biochem Cell Biol Source Type: research
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
We describe a case of a 39-year-old woman suffering from peri-umbilical pain and increased abdominal size for one year, anorexia, asthenia, weight loss, occasionally dysuria and dyspareunia, and four months amenorrhea. Laboratory data revealed cancer antigen 125 (CA-125) level of 132.3 U/mL, erythrocyte sedimentation rate of 42 mm/h, and gamma-globulins of 2.66 g/dL. Computed tomography scan showed loculated ascites. It was initially suspected a carcinomatous origin, but ascites evaluation was negative for malignant cells. Magnetic resonance imaging from another hospital showed endometrial heterogeneity. Therefore, an endo...
Source: Acta Medica Portuguesa - Category: Journals (General) Tags: Acta Med Port Source Type: research
A number of drugs already approved to treat parasitic infections, cancers, infertility and other conditions also show promise as antibiotic agents against staph and tuberculosis infections, according to a new study. Because these agents act against multiple targets within the bacteria, it may be harder for bacteria to develop resistance, say the researchers.
Source: ScienceDaily Headlines - Category: Science Source Type: news
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