Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice.

In this study, we further expand upon the existing literature by characterizing the baseline ABR characteristics of 100 inbred mouse strains, 47 of which are newly characterized for hearing function. We identify several distinct patterns of baseline hearing deficits and provide potential avenues for further investigation. Additionally, we characterize the sensitivity of the same 100 strains to noise exposure using permanent thresholds shifts, identifying several distinct patterns of noise-sensitivity. The resulting data provides a new resource for studying hearing loss and noise-sensitivity in mice. PMID: 26706709 [PubMed - as supplied by publisher]
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research