Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation

Conclusion
OA-NO2 potently inhibits atrial fibrosis and subsequent AF. Nitro-fatty acids and possibly other lipid electrophiles thus emerge as potential therapeutic agents for AF, either by increasing endogenous levels through dietary modulation or by administration as synthetic drugs.

Source: Cardiovascular Research - December 28, 2015 Category: Cardiology Authors: Rudolph, T. K., Ravekes, T., Klinke, A., Friedrichs, K., Mollenhauer, M., Pekarova, M., Ambrozova, G., Martiskova, H., Kaur, J.-J., Matthes, B., Schwoerer, A., Woodcock, S. R., Kubala, L., Freeman, B. A., Baldus, S., Rudolph, V. Tags: Ion Channels and Arrhythmias Source Type: research