HIF-2{alpha}-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction
Conclusions
These findings demonstrate that HIF-2α is clearly implicated in the TSP1 pulmonary regulation and provide new insights on its contribution to PAH-driven vascular remodelling and vasoconstriction.
Source: Cardiovascular Research - Category: Cardiology Authors: Labrousse-Arias, D., Castillo-Gonzalez, R., Rogers, N. M., Torres-Capelli, M., Barreira, B., Aragones, J., Cogolludo, A., Isenberg, J. S., Calzada, M. J. Tags: Vascular Biology Source Type: research