Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signalling

Conclusion
Our data demonstrate a dose-dependent relation between Pitx2 expression and the expression of AF susceptibility genes, calcium handling, and microRNAs and identify a complex regulatory network orchestrated by Pitx2 with large impact on atrial arrhythmogenesis susceptibility.

Source: Cardiovascular Research - December 28, 2015 Category: Cardiology Authors: Lozano-Velasco, E., Hernandez-Torres, F., Daimi, H., Serra, S. A., Herraiz, A., Hove-Madsen, L., Aranega, A., Franco, D. Tags: Cardiac biology and remodelling Source Type: research