Low sodium levels linked to poor targeted therapy outcomes

Low serum sodium levels in patients receiving targeted therapy for metastatic renal cell carcinoma (mRCC) may signal a poor outcome, study findings indicate.12/12/2013
Source: Kidney Cancer Association - Category: Cancer & Oncology Source Type: news

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ZNF492 and GPR149 methylation patterns as prognostic markers for clear cell renal cell carcinoma: Array‑based DNA methylation profiling. Oncol Rep. 2019 May 07;: Authors: Kim YJ, Jang W, Piao XM, Yoon HY, Byun YJ, Kim JS, Kim SM, Lee SK, Seo SP, Kang HW, Kim WT, Yun SJ, Shon HS, Ryu KH, Kim SW, Ha YS, Yoon GS, Lee SC, Kwon TG, Kim WJ Abstract The present study aimed to identify novel methylation markers of clear cell renal cell carcinoma (ccRCC) using microarray methylation analysis and evaluate their prognostic relevance in patient samples. To identify cancer‑specific methylated biomarkers, microa...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Jonasch E Abstract The NCCN Guidelines for Kidney Cancer have undergone a major shift in the risk categorization used for designating "preferred" and "other recommended" or "useful under certain circumstances" first-line treatments. In the most recent version of the guidelines, "favorable risk" is now its own risk category and "intermediate risk" and "poor risk" are combined into one category. The treatment recommendations for clear cell renal cell carcinoma are continually revised and more new options are anticipated based on encouraging results ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Conditions:   Breast Cancer;   Renal Cell Carcinoma Interventions:   Drug: IPI-549;   Drug: Atezolizumab;   Drug: nab-paclitaxel;   Drug: Bevacizumab Sponsors:   Infinity Pharmaceuticals, Inc.;   Roche Pharma AG Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Pan X, Zhao L, Quan J, Liu K, Lai Y, Li Z, Zhang Z, Xu J, Xu W, Guan X, Li H, Yang S, Gui Y, Chen Y, Lai Y Abstract Renal cell carcinoma (RCC) is a common cancer that accounts for about 1.6% of all malignancies. Accumulating evidence has shown that miRNAs may play important roles in the development of cancers and that these same miRNAs may serve as diagnostic and prognostic biomarkers. The role of the miRNA miR-378a-5p in RCC, however, has been largely unexplored. In our study, we have demonstrated that miR-378a-5p expression was decreased in renal tissues and in RCC cell lines compared with corresponding ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
The acquisition of Peloton, which was seeking to go public last week, brings its lead kidney cancer drug candidate to Merck, strengthening its renal cell carcinoma presence
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
In this study, we investigated FTH1 mRNA expression and its diagnostic and prognostic value in RCC. MATERIAL AND METHODS The mRNA expression of FTH1 was analyzed using including Oncomine, Gene Expression Omnibus, and Cancer Genome Atlas datasets, while the protein level of FTH1 was analyzed using the Human Protein Atlas database. The associations between FTH1 and clinicopathologic characteristics and survival time and Cox multivariate survival analysis were analyzed using SPSS 22.0 software. A meta-analysis was performed to assess consistency of FTH1 expression. GO, KEGG, and PPI analyses were used to predict biological fu...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Background and objective Current research shows that platelet to lymphocyte ratio (PLR) has important prognostic value in renal cell carcinoma, esophageal cancer, gastric cancer, liver cancer and colon cancer. The aim of the study is to evaluate the prognostic value of PLR in non-small cell lung cancer (NSCLC) through meta-analysis. Methods Literature search for PubMed, EMBASE, Web of Science, Medline, Cochrane Library, China National Knowledge Internet (CNKI), China Biomedical Medicine disc (CBMdisc), VIP, Wanfang Database using computer electronic system to study the association between PLR and overall survival (OS) and ...
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
We present a case of a 56-year-old male with a history of RCC, followed by the development of cutaneous metastases 4 years later with an uncommon clinical presentation. RCC is the most common genitourinary cancer to metastasize to the skin and accounts for 6.8% of cutaneous metastases. These patients have a poor prognosis. It is essential for these patients to perform a complete periodic dermatologic examination for proper restaging and treatment.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
AbstractCancer cells can escape the immune system by different mechanisms. The evasion of cancer cells from immune surveillance is prevented by immune checkpoint inhibitors, allowing the patient ’s own immune system to attack their cancer. Immune checkpoint inhibitors have shown improvement in overall survival for melanoma, lung cancer and renal cell carcinoma in clinical trials. Unfortunately, not all patients respond to this therapy.In cancer management, percutaneous ablation techniques are well established for both cure and local control of many tumour types. Cryoablation of the tumour tissue results in cell destr...
Source: Insights into Imaging - Category: Radiology Source Type: research
Publication date: August 2019Source: Biomedicine &Pharmacotherapy, Volume 116Author(s): Zhengmiao Wang, Yixuan Zhao, Ye Wang, Chunxiang JinAbstractCircular RNAs (circRNAs), a novel subgroup of non-coding RNAs (ncRNAs), have been reported in human cancers due to their significant regulatory roles. CircRNA Hippocampus Abundant Transcript 1 (circHIAT1) has been studied in clear cell renal cell carcinoma. However, whether it can regulate the tumorigenesis of hepatocellular carcinoma (HCC) remains unclear. The expression level of circHIAT1 in HCC samples and cell lines was measured by qRT-PCR analysis. CircHIAT1 was express...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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