Rexahn initiates Phase Ib clinical trial of RX-3117 for treatment of solid tumors
RX-3117 has broad spectrum anti-tumor activity against 80 different human cancer cell lines (including NSCLC, breast, ovarian, pancreas, colon, renal, brain, bladder, cervical) and efficacy in 12 different mouse xenograft models (including colorectal, non-small cell lung, pancreatic and renal cell carcinoma) superior to that of gemcitabine.01/10/2014
A growing link—what is the role of height in cancer risk?A growing link—what is the role of height in cancer risk?, Published online: 19 February 2019; doi:10.1038/s41416-018-0370-9A growing link—what is the role of height in cancer risk?
Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults, Published online: 19 February 2019; doi:10.1038/s41416-018-0371-8Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults
Publication date: Available online 18 February 2019Source: Research in Veterinary ScienceAuthor(s): Hong-Xia Wang, Xi-Lan Lu, Wen-Jie Huang, Jian-Min ZhangAbstractThe aim of this study was to investigate the role of pyroptosis in the cryopreservation and transplantation of mouse ovarian tissues; the effects of pyroptosis inhibitior on the ovarian graft function were also explored. ICR (institute of cancer research) mice were randomly divided into control group and experimental groups (n = 10 per group). The experimental groups included fresh graft group (autograft), cryopreserved graft group (cryopreservation + aut...
(MedPage Today) -- Also, how to prevent unplanned hospitalization for cancer patients
Lupron (leuprolide acetate) is a type of hormone therapy for people with prostate cancer. Lupron is an injection drug, and doctors often prescribe it in combination with radiation therapy or surgery. As it lowers a person ’s testosterone levels, Lupron can cause a range of side effects. Learn more here.
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00318E, PaperJosu é Carvalho, Jéssica Lopes Nunes, Ana Catarina Lopes, Maria Paula Cabral Campello, António Rocha Paulo, João António Queiroz, Carla Cruz DNA aptamers represent a way to target cancer cells at a molecular level and continue to be developed with a view to improve treatment and imaging in cancer medicine. AT11-L0,... The content of this RSS Feed (c) The Royal Society of Chemistry
In the present investigation, a collection of twenty two nerol derivatives, containing 1,2,3-triazolic appendages, was synthesized and screened in vitro for their cytotoxic activity against HL60, Nalm6, and Jurkat human leukemia cells as well as against B16F10 (melanoma cell line). In most cases, derivatives were able to reduce cell viability. The most potent compound (Z)-4-(((3,7-dimethylocta-2,6-dien-1-yl)oxy)methyl)-1-(4-(trifluoromethoxy)benzyl)-1H-1,2,3 triazole showed antiproliferative activity against Jurkat cells and reduced B16F10 cell migration. Physicochemical properties of the compounds were calculated in order...
Electrochemical methods are powerful in the characterization and design of redox-modulating agents. We, herein, report the electrochemical investigation, in aprotic medium, of eleven synthetic 3-thio-substituted-nor-beta-lapachones, along with the determination of cytotoxic activity and correspondent selectivity index, against several cancer cell lines and one normal cell. Four of the quinones are novel compounds. The redox behavior is representative of two independent systems: the easy reduction of the quinone moiety and, at far more negative potential, the reductive cleavage of the C-S-C bonding; and the anodic part cont...
Cancer is a complex disease which involves abnormalities of multiple cellular pathways. Current chemotherapeutic drugs are mainly designed to target the DNA and cell division. Therefore, in the present study, we have synthesized a new series of 1,2,3-triazolo-naphthalimide/phthalimide conjugates and evaluated their in vitro cytotoxicity against selected human cancer cells. Among the tested compounds, one of them displayed notable cytotoxic activity against A549 lung cancer cells with an IC50 (half maximal inhibitory concentration) value of 7.6 ± 0.78 µM. To determine the effect of this compound on cell viabili...
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C8CC10089F, CommunicationBarbara Souza, Svemir Rudic, Kirill Titov, Arun Babal, James D Taylor, Jin-Chong Tan A facile mechanochemical method was employed to accomplish one pot encapsulation of anti-cancer drug 5 Fluorouracil (5 FU as guest) in metal-organic framework (HKUST 1 as host). Vibrational spectroscopy via... The content of this RSS Feed (c) The Royal Society of Chemistry
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