Campylobacter concisus pathotypes are present at significant levels in patients with gastroenteritis.

Campylobacter concisus pathotypes are present at significant levels in patients with gastroenteritis. J Med Microbiol. 2015 Dec 23; Authors: Underwood AP, Kaakoush NO, Sodhi N, Merif J, Lee WS, Riordan SM, Rawlinson WD, Mitchell HM Abstract Given that Campylobacter jejuni is recognised as the most common cause of bacterial gastroenteritis worldwide, recent findings showing comparable levels of Campylobacter concisus in patients with gastroenteritis would suggest that this bacterium is clinically important. The prevalence and abundance of C. concisus in stool samples collected from patients with acute gastroenteritis was examined using quantitative real-time PCR. The associated virulence determinants exotoxin 9 and zonula occludens toxin DNA were detected for C. concisus infected samples using real-time PCR. C. concisus was detected at high prevalence in patients with gastroenteritis (49.7%), higher than that observed for C. jejuni (~5%). The levels of C. concisus were putatively classified into clinically relevant and potentially transient subgroups based on a threshold developed using C. jejuni levels, as the highly sensitive real-time PCR likely detected transient passage of the bacterium from the oral cavity. A total of 18% of patients were found to have clinically relevant levels of C. concisus, a significant number of which also had high levels of one of the virulence determinants. Of these patients, 78% were found to have no ot...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research