Behind the Headlines' Top Five of Top Fives 2015
In this study, researchers wanted to see why this is and if there could be any human applications.Researchers collected white blood cells from African and Asian elephants. They found that elephants have at least 20 copies of a gene called TP53. TP53 is known to encourage cell "suicide" when DNA is damaged, stopping any potential cancer in its tracks. In contrast, humans are thought to have only a single copy of the TP53 gene.Of course the big question – the elephant in the room, if you will – is how we can boost TP53 activity in humans to stimulate a similar protective effect. The simple answer is: we don't know. Yet. Researchers 'a step closer' to universal flu vaccineIt's just like buses. You wait years for a potential universal flu vaccine, then two come along at once. In August, two studies were published, both on the possibility of creating a "one-size jab" for flu.The flu virus is shaped like a ball, with many "spikes" sticking out of its surface made of a chemical called haemagglutinin. The "stem" part of this spike does not change as much as its tip or other parts of the virus, so both of these studies aimed to develop a vaccine that targeted the stem. Targeting these areas may help keep the vaccines effective, even if new strains come along.Both vaccines were able to protect mice against what would usually be a lethal dose of flu, and one vaccine reduced fever symptoms in monkeys.While the results were encouraging, ...
This study compares the cost-effectiveness of routine versus selective pre-procedure INR testing.
To analyze a prospective cohort of patients undergoing routine image-guided bone and soft tissue biopsies of the extremities using revised criteria for requiring preprocedural lab tests (CBC and INR) and stopping aspirin. 1. The aim was to assess whether the revised criteria resulted in an increased bleeding complication rate. 2. To evaluate if the revised criteria would decrease the time from the biopsy being ordered to when the biopsy was performed.
The American Society of Anesthesiologists (ASA) standards were updated in 2011 to recommend end-tidal carbon dioxide (EtCO2) monitoring during moderate sedation, which is now common practice in IR. Studies show EtCO2 monitoring improves detection of respiratory depression and hypoxemia. The purpose of this study was to evaluate the incidence of respiratory depression and hypoxemia from oversedation during IR procedures before and after implementation of EtCO2 monitoring.
Pre-procedure correction coagulopathy is of high priority in patients undergoing minimally invasive IR procedures. Unnecessary transfusion of blood products is associated with well-known infectious and non-infectious risks, however, uncorrected coagulopathy in the perioperative setting can be detrimental to the patient. Therefore, determining safe thresholds for administration of blood products is imperative, which in interventional radiology is mostly governed by the SIR consensus guidelines. The purpose of this study is to assess whether a single institution ’s restrictive approach to pre-procedural transfusion of ...
To study outcomes and factors that predict success of transarterial (TA) and translumbar (TL) embolization of type 2 endoleaks following endovascular aortic aneurysm repair (EVAR).
EVAR can result in high radiation dose to patients and operators. Optimal imaging is required for safe stent graft deployment. While DSA provides high quality images, radiation dose rate is increased compared to digital fluoroscopy (DF). The aim of this prospective randomized study was to assess if radiation dose in EVAR could be reduced by predominantly utilizing DF for implantation compared to the standard DSA-utilized technique.
The objective of this compound is to decrease the rate of rectal toxicity related to radiation therapy, by creating a gap between the prostate and rectum. Secondary benefits include decreased urinary complications and improved sexual quality of life. The hydrogel spacer maintains space for approximately 3 months, and is absorbed in about 6 months.
To evaluate the efficacy and clinical impact of 3 Tesla in-bore trans-rectal magnetic resonance-guided biopsy (3T MRGB) for prostate cancer (PCa) detection based on PIRADSv2 in patients with either suspected prostate cancer or under active surveillance.
To evaluate the usage pattern, feasibility, and complications associated with use of the Solopath Introducer System (Terumo Medical; Tokyo, Japan), a balloon-expandable, re-collapsible sheath in patients undergoing thoracic aortic endovascular repair (TEVAR).
Many patients with mucinous peritoneal tumours achieve long-term recurrence free and overall survival from cytoreductive surgery and intraperitoneal chemotherapy, however recurrence is frequently seen. Repeat surgical interventions have a negative impact on quality of life, risks may outweigh any potential benefits and repeated admissions have a considerable impact on healthcare systems. The deconditioned patient is eventually deemed inoperable with no treatment option for their disease. In an attempt to modify these outcomes, we discovered remarkable synergy in extensive preclinical studies between Bromelain (Br) and Acetylcysteine (NAC).
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