Boy, 9, has testicular tissue frozen in hope of having children

Nathan Crawford becomes first in UK to undergo process, having been diagnosed with brain tumour requiring treatment that risks making him infertileA nine-year-old boy with a brain tumour has become the first person in the UK to have testicular tissue frozen in the hope that he can have children later in life.Nathan Crawford has undergone radiotherapy and chemotherapy to shrink his tumour, which is inoperable, but the treatment could make him infertile. In a groundbreaking procedure, surgeons at the John Radcliffe hospital in Oxford have removed and frozen a wedge of testicular tissue, with the aim that it is one day re-implanted into Nathan. Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: UK news Science Oxford Cornwall Medical research Source Type: news

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Abstract Here we describe a method for identifying genes and genetic pathways responsible for chemoresistance in cancer cells. The method is based on generation and characterization of matched pairs of chemotherapy-sensitive/chemotherapy-resistant cancer cell lines. In this protocol we are using endometrial cancer cell lines treated with carboplatin and paclitaxel, which are first-line chemotherapies for gynecologic malignancies. The chemoresistant cells and their chemosensitive counterparts are used for downstream applications including bulk RNA-sequencing analysis to identify a set of genes and pathways that are...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
We describe major advances in the cellular and molecular subtypes based on next generation sequencing and their predictive and prognostic value in PDAC patients. We review aberrant genes involving in defined cellular processes in PDAC. Finally, the current state of drug development with novel investigational agents targeting cell fate, cell survival, genomic instability, tumor-stroma and immune checkpoints are discussed. Expert Opinion: Molecular techniques have revealed distinct driver mutations in PDAC. Common genes and cellular processes are dysregulated in the pathogenesis of PDAC. These cellular processes categorized ...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
AbstractChemotherapy-induced gonadal dysfunction resulting in transient or persistent infertility depends on the type of drugs and cumulative dose, and it is an important long-term complication, especially for adolescent and young adult (AYA) cancer patients. Due to its importance, a clinical practice guideline for fertility preservation in childhood and AYA cancer patients was published by the Japan Society of Clinical Oncology (JSCO) in 2017. Although the precise mechanisms remain unclear, several studies reported that the cancer itself, not the cancer treatment, adversely affected semen quality. It is reported that that...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Tosoni A, Balestrini D, Brandes AA Abstract INTRODUCTION: Fertility impairment due to treatments is a major concern for adolescents and young adult patients who survived cancer. Areas covered: Chemotherapy may determine a detrimental effect on ovary function, leading to infertility, and premature ovarian failure. Embryo and oocyte cryopreservation is a standard strategy for fertility preservation; other strategies, such as gonadal tissue cryopreservation and the use of gonadotropin -releasing hormone agonist, are still considered experimental. There are few data available regarding the effect of pregnancy ...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
I’ve written several times over the years about the overblown claims of harm attributed, largely—but not exclusively—by cranks, to cell phone radiation. It’s been claimed that radiation from cell phones can cause brain tumors (there’s no convincing evidence that this is true), breast cancer (the evidence for these claims is so incredibly flimsy—and featured by…
Source: Respectful Insolence - Category: Surgery Authors: Tags: Clinical trials Complementary and alternative medicine Popular culture Pseudoscience Quackery Skepticism/critical thinking cell phone infertility male factor infertility Martha Dirnfeld mobile phone radio waves sperm Technion Uni Source Type: blogs
Authors: Auriemma RS, Grasso LF, Pivonello R, Colao A Abstract INTRODUCTION: Prolactinomas are the most common hormone-secreting pituitary tumors, accounting for approximately 40% of all pituitary tumors. Infertility, gonadal and sexual dysfunction are usually the most relevant clinical features in both sexes. Area covered: This review focuses on safety and tolerability of therapeutic approaches for prolactinomas. Complications from trans-sphenoidal surgery vary depending on tumor size, and mortality rate ranges 0.6%-31% for patients with microprolactinomas and macroprolactinoms, respectively. More than 50% of pati...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Nathan Crawford becomes first in UK to undergo process, having been diagnosed with brain tumour requiring treatment that risks making him infertileA nine-year-old boy with a brain tumour has become the first person in the UK to have testicular tissue frozen in the hope that he can have children later in life.Nathan Crawford has undergone radiotherapy and chemotherapy to shrink his tumour, which is inoperable, but the treatment could make him infertile. In a groundbreaking procedure, surgeons at the John Radcliffe hospital in Oxford have removed and frozen a wedge of testicular tissue, with the aim that it is one day re-imp...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science UK news Oxford Cornwall Medical research Source Type: news
Nathan Crawford has become the first person in Britain to have a wedge of testicular tissue removed and frozen before cancer treatment
Source: Telegraph Health - Category: Consumer Health News Tags: chemotherapy chance infertility tissue radiatherapy sperm frozen cancer oxford risk men Source Type: news
Sue Perkins discusses her first boyfriend, falling in love and finding out she's infertile
Source: The Telegraph : Health Advice - Category: Consumer Health News Tags: biological clock brain tumour memoir Great British Bake Off adoption GBBO Sue Perkins gay Spectacles Anna Richardson Source Type: news
GBBO star Sue Perkins, 45, has revealed that while learning the news that her benign brain tumour has left her infertile, she was the victim of cruel homophobia at the hands of a consultant.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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