Boy, 9, has testicular tissue frozen in hope of having children

Nathan Crawford becomes first in UK to undergo process, having been diagnosed with brain tumour requiring treatment that risks making him infertileA nine-year-old boy with a brain tumour has become the first person in the UK to have testicular tissue frozen in the hope that he can have children later in life.Nathan Crawford has undergone radiotherapy and chemotherapy to shrink his tumour, which is inoperable, but the treatment could make him infertile. In a groundbreaking procedure, surgeons at the John Radcliffe hospital in Oxford have removed and frozen a wedge of testicular tissue, with the aim that it is one day re-implanted into Nathan. Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: UK news Science Oxford Cornwall Medical research Source Type: news

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Authors: Smith CA, Kachnic LA Abstract Locally advanced rectal cancer (LARC) carries higher risks of local and distant recurrence when treated with surgical resection alone. Multiple treatment strategies have been investigated to reduce recurrence risk and improve survival. Currently, there are 3 primary strategies for managing LARC: (1) preoperative long-course radiotherapy (RT) combined with radiosensitizing chemotherapy, which is better tolerated than postoperative chemoradiotherapy and provides tumor downstaging and improved pathologic complete response (pCR), followed by postoperative chemotherapy; (2) preoper...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Authors: Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Engstrom PF, Grem JL, Grothey A, Hochster HS, Hoffe S, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Mulcahy MF, Murphy JD, Nurkin S, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Wuthrick E, Gregory KM, Gurski L, Freedman-Cass DA Abstract The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Rectal Cancer address diagnosis, staging, surgical management, perioperative treatment, management of recurrent an...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Authors: Kozak MM, Jacobson CE, von Eyben R, Pollom EL, Telli M, Horst KC Abstract Purpose: We sought to evaluate whether pathologic nodal response was predictive of outcomes in women aged ≤40 years with breast cancer treated with neoadjuvant chemotherapy (NAC). Methods: A total of 220 patients treated with NAC between 1991 and 2015 were retrospectively reviewed. Pathologic complete response (pCR) was defined as no evidence of residual invasive tumor in the breast and lymph nodes (LNs) (ypT0/Tis ypN0); partial response if there was no tumor in the LNs but residual tumor in the breast (ypT+ ypN0) or residual tumo...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Authors: Tosoni A, Balestrini D, Brandes AA Abstract INTRODUCTION: Fertility impairment due to treatments is a major concern for adolescents and young adult patients who survived cancer. Areas covered: Chemotherapy may determine a detrimental effect on ovary function, leading to infertility, and premature ovarian failure. Embryo and oocyte cryopreservation is a standard strategy for fertility preservation; other strategies, such as gonadal tissue cryopreservation and the use of gonadotropin -releasing hormone agonist, are still considered experimental. There are few data available regarding the effect of pregnancy ...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
I’ve written several times over the years about the overblown claims of harm attributed, largely—but not exclusively—by cranks, to cell phone radiation. It’s been claimed that radiation from cell phones can cause brain tumors (there’s no convincing evidence that this is true), breast cancer (the evidence for these claims is so incredibly flimsy—and featured by…
Source: Respectful Insolence - Category: Surgery Authors: Tags: Clinical trials Complementary and alternative medicine Popular culture Pseudoscience Quackery Skepticism/critical thinking cell phone infertility male factor infertility Martha Dirnfeld mobile phone radio waves sperm Technion Uni Source Type: blogs
Authors: Auriemma RS, Grasso LF, Pivonello R, Colao A Abstract INTRODUCTION: Prolactinomas are the most common hormone-secreting pituitary tumors, accounting for approximately 40% of all pituitary tumors. Infertility, gonadal and sexual dysfunction are usually the most relevant clinical features in both sexes. Area covered: This review focuses on safety and tolerability of therapeutic approaches for prolactinomas. Complications from trans-sphenoidal surgery vary depending on tumor size, and mortality rate ranges 0.6%-31% for patients with microprolactinomas and macroprolactinoms, respectively. More than 50% of pati...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Nathan Crawford becomes first in UK to undergo process, having been diagnosed with brain tumour requiring treatment that risks making him infertileA nine-year-old boy with a brain tumour has become the first person in the UK to have testicular tissue frozen in the hope that he can have children later in life.Nathan Crawford has undergone radiotherapy and chemotherapy to shrink his tumour, which is inoperable, but the treatment could make him infertile. In a groundbreaking procedure, surgeons at the John Radcliffe hospital in Oxford have removed and frozen a wedge of testicular tissue, with the aim that it is one day re-imp...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science UK news Oxford Cornwall Medical research Source Type: news
Nathan Crawford has become the first person in Britain to have a wedge of testicular tissue removed and frozen before cancer treatment
Source: Telegraph Health - Category: Consumer Health News Tags: chemotherapy chance infertility tissue radiatherapy sperm frozen cancer oxford risk men Source Type: news
Sue Perkins discusses her first boyfriend, falling in love and finding out she's infertile
Source: The Telegraph : Health Advice - Category: Consumer Health News Tags: biological clock brain tumour memoir Great British Bake Off adoption GBBO Sue Perkins gay Spectacles Anna Richardson Source Type: news
GBBO star Sue Perkins, 45, has revealed that while learning the news that her benign brain tumour has left her infertile, she was the victim of cruel homophobia at the hands of a consultant.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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